The Selective Membrane Filtration of an ESF-generating Factor (EGF) in the Presence of Erythropoietin (ESF)

J. P. Lewis, Emily T. Welch, W. A. Neal, R. R. Moores, W. G. Lewis, C. S. Wright, C. M. Dubose, Linda L. Smith

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

A mixture of an erythropoiesis stimulating factor (ESF) and an ESF-generating factor (EGF), isolated from the urine of a patient with paroxysmal nocturnal hemoglobinuria (PNH), was separated by selective membrane filtration. The optimum pH for activity of the EGF fraction from the urine of the PNH patient was about 7.4, the same as that previously found for the EGF from the urine of a patient with an anemia secondary to multiple myeloma (MM). The urine from the PNH patient contained an ESF that appeared larger than EGF, whereas the urine from the MM patient did not; the urine from both patients, however, contained an ESF that appeared smaller than EGF as previously noted.

Original languageEnglish (US)
Pages (from-to)322-324
Number of pages3
JournalProceedings of the Society for Experimental Biology and Medicine
Volume138
Issue number1
DOIs
StatePublished - Oct 1971

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    Lewis, J. P., Welch, E. T., Neal, W. A., Moores, R. R., Lewis, W. G., Wright, C. S., Dubose, C. M., & Smith, L. L. (1971). The Selective Membrane Filtration of an ESF-generating Factor (EGF) in the Presence of Erythropoietin (ESF). Proceedings of the Society for Experimental Biology and Medicine, 138(1), 322-324. https://doi.org/10.3181/00379727-138-35888