The specific T-cell response to antigenic peptides is influenced by bystander peptides

Izabela Nowak, Elzbieta Pajtasz-Piasecka, Bartosz Chmielowski, Leszek Ignatowicz, Piotr Kuśnierczyk

Research output: Contribution to journalArticle

Abstract

T lymphocytes recognize antigens in the form of peptides presented by major histocompatibility complex (MHC) molecules on the cell surface. Only a small proportion of MHC class I and class II molecules are loaded with foreign antigenic peptides; the vast majority are loaded with thousands of different self peptides. It was suggested that MHC molecules presenting self peptides may serve either to decrease (antagonistic effect) or increase (synergistic effect) the T cell response to a specific antigen. Here, we present our finding that transfected mouse fibroblasts presenting a single antigenic peptide covalently bound to a class II MHC molecule stimulated specific mouse T cell hybridoma cells to an interleukin-2 response less efficiently than fibroblasts presenting a similar amount of antigenic peptide in the presence of class II molecules loaded with heterogenous bystander peptides.

Original languageEnglish (US)
Pages (from-to)70-79
Number of pages10
JournalCellular and Molecular Biology Letters
Volume11
Issue number1
DOIs
StatePublished - Jan 1 2006

Keywords

  • Bystander peptide
  • Mouse model
  • T cell response
  • Transfectants

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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    Nowak, I., Pajtasz-Piasecka, E., Chmielowski, B., Ignatowicz, L., & Kuśnierczyk, P. (2006). The specific T-cell response to antigenic peptides is influenced by bystander peptides. Cellular and Molecular Biology Letters, 11(1), 70-79. https://doi.org/10.2478/s11658-006-0007-5