The synergistic action of ethanol and nerve growth factor in the induction of neuronal nitric oxide synthase

Yume T. Phung, Stephen M. Black

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Ethanol alone had no effect on neuronal nitric oxide synthase (nNOS) expression in PC12 cells. However, in the presence of nerve growth factor (NGF), nNOS expression was amplified (threefold, P < 0.05), compared to NGF alone. This increase was eliminated with pretreatment of PC12 cells with staurosporine, suggesting that the effects of ethanol on nNOS expression are mediated by a protein kinase C-dependent pathway.

Original languageEnglish (US)
Pages (from-to)506-510
Number of pages5
JournalAlcohol and Alcoholism
Volume34
Issue number4
DOIs
StatePublished - Aug 17 1999

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Toxicology
  • Psychiatry and Mental health

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