The synergistic action of ethanol and nerve growth factor in the induction of neuronal nitric oxide synthase

Yume T. Phung; Stephen M. Black

doi:10.1093/alcalc/34.4.506

The synergistic action of ethanol and nerve growth factor in the induction of neuronal nitric oxide synthase

Yume T. Phung, Stephen M. Black

Obstetrics and Gynecology

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Ethanol alone had no effect on neuronal nitric oxide synthase (nNOS) expression in PC12 cells. However, in the presence of nerve growth factor (NGF), nNOS expression was amplified (threefold, P < 0.05), compared to NGF alone. This increase was eliminated with pretreatment of PC12 cells with staurosporine, suggesting that the effects of ethanol on nNOS expression are mediated by a protein kinase C-dependent pathway.

Original language	English (US)
Pages (from-to)	506-510
Number of pages	5
Journal	Alcohol and Alcoholism
Volume	34
Issue number	4
DOIs	https://doi.org/10.1093/alcalc/34.4.506
State	Published - 1999

ASJC Scopus subject areas

Medicine (miscellaneous)
Toxicology
Psychiatry and Mental health

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