TY - JOUR
T1 - The synergistic action of ethanol and nerve growth factor in the induction of neuronal nitric oxide synthase
AU - Phung, Yume T.
AU - Black, Stephen M.
PY - 1999
Y1 - 1999
N2 - Ethanol alone had no effect on neuronal nitric oxide synthase (nNOS) expression in PC12 cells. However, in the presence of nerve growth factor (NGF), nNOS expression was amplified (threefold, P < 0.05), compared to NGF alone. This increase was eliminated with pretreatment of PC12 cells with staurosporine, suggesting that the effects of ethanol on nNOS expression are mediated by a protein kinase C-dependent pathway.
AB - Ethanol alone had no effect on neuronal nitric oxide synthase (nNOS) expression in PC12 cells. However, in the presence of nerve growth factor (NGF), nNOS expression was amplified (threefold, P < 0.05), compared to NGF alone. This increase was eliminated with pretreatment of PC12 cells with staurosporine, suggesting that the effects of ethanol on nNOS expression are mediated by a protein kinase C-dependent pathway.
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U2 - 10.1093/alcalc/34.4.506
DO - 10.1093/alcalc/34.4.506
M3 - Article
C2 - 10456578
AN - SCOPUS:0032779420
VL - 34
SP - 506
EP - 510
JO - Alcohol and Alcoholism
JF - Alcohol and Alcoholism
SN - 0735-0414
IS - 4
ER -