Abstract
Ethanol alone had no effect on neuronal nitric oxide synthase (nNOS) expression in PC12 cells. However, in the presence of nerve growth factor (NGF), nNOS expression was amplified (threefold, P < 0.05), compared to NGF alone. This increase was eliminated with pretreatment of PC12 cells with staurosporine, suggesting that the effects of ethanol on nNOS expression are mediated by a protein kinase C-dependent pathway.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 506-510 |
| Number of pages | 5 |
| Journal | Alcohol and Alcoholism |
| Volume | 34 |
| Issue number | 4 |
| DOIs | |
| State | Published - Aug 17 1999 |
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ASJC Scopus subject areas
- Medicine (miscellaneous)
- Toxicology
- Psychiatry and Mental health
Cite this
The synergistic action of ethanol and nerve growth factor in the induction of neuronal nitric oxide synthase. / Phung, Yume T.; Black, Stephen M.
In: Alcohol and Alcoholism, Vol. 34, No. 4, 17.08.1999, p. 506-510.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The synergistic action of ethanol and nerve growth factor in the induction of neuronal nitric oxide synthase
AU - Phung, Yume T.
AU - Black, Stephen M.
PY - 1999/8/17
Y1 - 1999/8/17
N2 - Ethanol alone had no effect on neuronal nitric oxide synthase (nNOS) expression in PC12 cells. However, in the presence of nerve growth factor (NGF), nNOS expression was amplified (threefold, P < 0.05), compared to NGF alone. This increase was eliminated with pretreatment of PC12 cells with staurosporine, suggesting that the effects of ethanol on nNOS expression are mediated by a protein kinase C-dependent pathway.
AB - Ethanol alone had no effect on neuronal nitric oxide synthase (nNOS) expression in PC12 cells. However, in the presence of nerve growth factor (NGF), nNOS expression was amplified (threefold, P < 0.05), compared to NGF alone. This increase was eliminated with pretreatment of PC12 cells with staurosporine, suggesting that the effects of ethanol on nNOS expression are mediated by a protein kinase C-dependent pathway.
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UR - http://www.scopus.com/inward/citedby.url?scp=0032779420&partnerID=8YFLogxK
U2 - 10.1093/alcalc/34.4.506
DO - 10.1093/alcalc/34.4.506
M3 - Article
C2 - 10456578
AN - SCOPUS:0032779420
VL - 34
SP - 506
EP - 510
JO - Alcohol and Alcoholism
JF - Alcohol and Alcoholism
SN - 0735-0414
IS - 4
ER -