Abstract
Ethanol alone had no effect on neuronal nitric oxide synthase (nNOS) expression in PC12 cells. However, in the presence of nerve growth factor (NGF), nNOS expression was amplified (threefold, P < 0.05), compared to NGF alone. This increase was eliminated with pretreatment of PC12 cells with staurosporine, suggesting that the effects of ethanol on nNOS expression are mediated by a protein kinase C-dependent pathway.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 506-510 |
| Number of pages | 5 |
| Journal | Alcohol and Alcoholism |
| Volume | 34 |
| Issue number | 4 |
| DOIs | |
| State | Published - Aug 17 1999 |
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Toxicology
- Psychiatry and Mental health
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Phung, Y. T., & Black, S. M. (1999). The synergistic action of ethanol and nerve growth factor in the induction of neuronal nitric oxide synthase. Alcohol and Alcoholism, 34(4), 506-510. https://doi.org/10.1093/alcalc/34.4.506