The toll of the gridiron: Damage-associated molecular patterns and hypertension in American football

Cameron G. McCarthy, R. Clinton Webb

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

American football has unequivocally been linked to elevations in blood pressure and hypertension, especially in linemen. However, the mechanisms of this increase cannot be attributed solely to increased body weight and associated cardiometabolic risk factors (e.g., dyslipidemia or hyperglycemia). Therefore, understanding the etiology of football-associated hypertension is essential for improving the quality of life in this mostly young population, as well as for lowering the potential for chronic disease in the future. We propose that inflammatogenic damage-associated molecular patterns (DAMPs) released into the circulation from football-induced musculoskeletal trauma activate pattern-recognition receptors of the innate immune system - specifically, high mobility group box 1 protein (HMGB1) and mitochondrial (mt)DNA which activate Toll-like receptor (TLR)4 and -9, respectively. Previously, we observed that circulating levels of these 2 DAMPs are increased in hypertension, and activation of TLR4 and -9 causes endothelial dysfunction and hypertension. Therefore, our novel hypothesis is that musculoskeletal injury from repeated hits in football players, particularly in linemen, leads to elevated circulating HMGB1 and mtDNA to activate TLRs on endothelial cells leading to impaired endothelium-dependent vasodilation, increased vascular tone, and hypertension.

Original languageEnglish (US)
Pages (from-to)34-40
Number of pages7
JournalFASEB Journal
Volume30
Issue number1
DOIs
StatePublished - Jan 1 2016

Fingerprint

HMGB1 Protein
Football
Mitochondrial DNA
Hypertension
Pattern Recognition Receptors
Toll-Like Receptor 4
Immune system
Endothelial cells
Blood pressure
Chemical activation
Toll-Like Receptor 9
Wounds and Injuries
Dyslipidemias
Vasodilation
Hyperglycemia
Endothelium
Blood Vessels
Immune System
Chronic Disease
Endothelial Cells

Keywords

  • Blood pressure
  • Inflammation
  • Musculoskeletal trauma

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Genetics

Cite this

The toll of the gridiron : Damage-associated molecular patterns and hypertension in American football. / McCarthy, Cameron G.; Webb, R. Clinton.

In: FASEB Journal, Vol. 30, No. 1, 01.01.2016, p. 34-40.

Research output: Contribution to journalArticle

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