The value of oocyte reinsemination in human in vitro fertilization

J. Boldt, A. M. Howe, W. J. Butler, P. G. McDonough, S. L. Padilla

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19 Scopus citations

Abstract

The value of oocyte reinsemination in human in vitro fertilization (IVF) was evaluated in this study. Two groups of 25 cycles each were studied. In group 1 cycles, insemination of mature/questionably mature oocytes (judged by cumulus and corona cell appearance) at 6.5 hours postcollection yielded a fertilization rate of 42.3%. This value was significantly lower than that obtained with reinsemination (70.8%). In group 2, questionably mature oocytes were treated as immature and inseminated 24 to 30 hours postcollection. The fertilization rate of mature eggs in group 2 was 68.2%, with a reinsemination success rate of 40%. Triploidy rates and cleavage rates of mature eggs, fertilized either at initial insemination or reinsemination and of fertilized immature eggs, were similar within group 1 and group 2 cycles. In group 1, two pregnancies resulted from transfer of embryos arising solely from successful reinsemination, with one infant delivered. These results indicate that reinsemination offers a useful adjunct for IVF in cases where fertilization failure occurs.

Original languageEnglish (US)
Pages (from-to)617-623
Number of pages7
JournalFertility and sterility
Volume48
Issue number4
DOIs
Publication statusPublished - Jan 1 1987

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ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

Cite this

Boldt, J., Howe, A. M., Butler, W. J., McDonough, P. G., & Padilla, S. L. (1987). The value of oocyte reinsemination in human in vitro fertilization. Fertility and sterility, 48(4), 617-623. https://doi.org/10.1016/S0015-0282(16)59474-6