The Y-chromosome and reproductive disorders

Paul G McDonough

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Over the past decade the tools of modern molecular biology have provided unique insights into our fundamental understanding of developmental systems. These insights have been gleaned from the study of a wide variety of model organisms including yeast (Saccharomyces cerevisiae), fly (Drosophila), worm (Caenorhabditis elegans), and mouse. In man, the first analysis of developmental systems started with sexual differentiation and focused on the role of Y-linked genes. The presence of living developmental mutants in man affecting sexual development and the early technology of deletion mapping facilitated the isolation and identification of small segments of putative DNA suspected to contain sex-determining genes. The isolation of genes such as SRY (Sex Related gene on Y) has provided the first insights into the molecular biology of human sexual differentiation. The focus on the Y chromosome has brought further insights into chromosomal pairing, statural determinants in man, oncogenesis, spermatogenesis, haploid genomes, and the lineage of man himself. This paper provides the circumstantial and direct evidence to illustrate the importance of the Y chromosome in reproductive disorders, and in the analysis of haploid genomes.

Original languageEnglish (US)
Pages (from-to)1-16
Number of pages16
JournalReproduction, Fertility and Development
Volume10
Issue number1
DOIs
StatePublished - Jan 1 1998

Fingerprint

Chromosome Disorders
reproductive disorders
chromosome aberrations
Y Chromosome
Y chromosome
sexual development
Sex Differentiation
Haploidy
Molecular Biology
sry Genes
haploidy
Y-Linked Genes
molecular biology
Genome
genes
Sexual Development
Caenorhabditis elegans
Spermatogenesis
Systems Analysis
Diptera

ASJC Scopus subject areas

  • Biotechnology
  • Reproductive Medicine
  • Animal Science and Zoology
  • Molecular Biology
  • Genetics
  • Endocrinology
  • Developmental Biology

Cite this

The Y-chromosome and reproductive disorders. / McDonough, Paul G.

In: Reproduction, Fertility and Development, Vol. 10, No. 1, 01.01.1998, p. 1-16.

Research output: Contribution to journalArticle

McDonough, Paul G. / The Y-chromosome and reproductive disorders. In: Reproduction, Fertility and Development. 1998 ; Vol. 10, No. 1. pp. 1-16.
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