The yin and yang of retinoic acid signaling in kidney diseases

Research output: Contribution to journalReview articlepeer-review

Abstract

Retinoic acid (RA) signaling is involved in various physiological and pathological conditions, including development, tumorigenesis, inflammation, and tissue damage and repair. In kidneys, the beneficial effect of RA has been reported in multiple disease models, such as glomerulosclerosis, renal fibrosis, and acute kidney injury. In this issue of the JCI, Chen et al. report a pathway activated by RA signaling that is mediated by the retinoic acid receptor responder protein 1 (RARRES1). Specifically, RARRES1, which is proteolytically cleaved to release the extracellular domain, was endocytosed by podocytes to induce apoptosis and glomerular dysfunction kidney disease. These findings unveil the contrasting aspects, a Janus face, of RA signaling that may guide its therapeutic use.

Original languageEnglish (US)
Pages (from-to)5124-5126
Number of pages3
JournalJournal of Clinical Investigation
Volume130
Issue number10
DOIs
StatePublished - Oct 1 2020

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint

Dive into the research topics of 'The yin and yang of retinoic acid signaling in kidney diseases'. Together they form a unique fingerprint.

Cite this