Theophylline therapy for near-fatal cheyne-stokes respiration. A case report

Catherine A. Pesek, Ryan Cooley, Krzysztof Narkiewicz, Mark Dyken, Neal Lee Weintraub, Virend K. Somers

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Background: Cheyne-Stokes respiration is characterized by periodic breathing that alternates with hypopnea or apnea. Objective: To describe the effect of theophylline on near-fatal Cheyne-Stokes respiration. Design: Case report. Setting: Tertiary referral center. Patient: A 48-year-old diabetic woman with a history of three cardiorespiratory arrests, a normal coronary arteriogram, normal left ventricular function, and severe Cheyne-Stokes respiration. Measurements: Oxygen saturation, intra-arterial blood pressure, central venous pressure, chest wall movement, electrocardiography, electromyography, electroencephalography, electro-oculography, minute ventilation, arterial blood gases, and serum theophylline levels. Results: After intravenous administration of 1.2 mg of theophylline at 0.6 mg/kg per hour (serum level, 5.6 μg/ mL), both Cheyne-Stokes respiration and oxygen desaturation were markedly attenuated. After infusion of 2.4 mg of theophylline (serum level, 11.6 μg/mL), Cheyne-Stokes respiration resolved completely. No change was seen with placebo. Cheyne-Stokes respiration did not recur during outpatient treatment with oral theophylline. Conclusion: Theophylline may be a rapid and effective therapy for life-threatening Cheyne-Stokes respiration.

Original languageEnglish (US)
Pages (from-to)427-430
Number of pages4
JournalAnnals of internal medicine
Volume130
Issue number5
DOIs
StatePublished - Mar 2 1999
Externally publishedYes

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Cheyne-Stokes Respiration
Theophylline
Therapeutics
Serum
Oxygen
Central Venous Pressure
Thoracic Wall
Electromyography
Apnea
Left Ventricular Function
Tertiary Care Centers
Intravenous Administration
Ventilation
Electroencephalography
Arterial Pressure
Electrocardiography
Respiration
Outpatients
Gases
Placebos

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Theophylline therapy for near-fatal cheyne-stokes respiration. A case report. / Pesek, Catherine A.; Cooley, Ryan; Narkiewicz, Krzysztof; Dyken, Mark; Weintraub, Neal Lee; Somers, Virend K.

In: Annals of internal medicine, Vol. 130, No. 5, 02.03.1999, p. 427-430.

Research output: Contribution to journalArticle

Pesek, Catherine A. ; Cooley, Ryan ; Narkiewicz, Krzysztof ; Dyken, Mark ; Weintraub, Neal Lee ; Somers, Virend K. / Theophylline therapy for near-fatal cheyne-stokes respiration. A case report. In: Annals of internal medicine. 1999 ; Vol. 130, No. 5. pp. 427-430.
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