Theophyllinylpyrimidine scaffolds undergo intramolecular cyclization reactions to form 1,3-diazepines and imidazopurines

Iryna Oleksandrivna Lebedyeva, V'Yacheslav M. Povstyanoy, Aleksey B. Ryabitskii, Oleksandr Panasyuk, Evgen Ivahnenko, Vera P. Lozova, Igor Markevich, Svitlana Allakhverdova, Mykhaylo V. Povstyanoy

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Polyheterocyclic pyrimidinyltheophyllines have been synthesized from pyrimidine and theophylline precursors. Attempts to cyclize these reactive bis-heterocyclic systems resulted in the formation of the corresponding diazepine moieties. In addition, modification of the reaction conditions led to the formation of imidazo[2,1-f]purines. Polyheterocyclic pyrimidinyltheophyllines have been synthesized from pyrimidine and theophylline precursors. Attempts to cyclize these reactive bis-heterocyclic systems resulted in the formation of the diazepine moiety. Modification of the reaction conditions led to the formation of imidazo[2,1-f]purines.

Original languageEnglish (US)
Pages (from-to)4594-4606
Number of pages13
JournalEuropean Journal of Organic Chemistry
Issue number21
DOIs
StatePublished - Jul 1 2013

Fingerprint

Purines
Forms (concrete)
Cyclization
Theophylline
Scaffolds
purines
pyrimidines
pyrimidine

Keywords

  • Alkaloids
  • Cyclization
  • Fused-ring systems
  • Medicinal chemistry
  • Nitrogen heterocycles

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Organic Chemistry

Cite this

Theophyllinylpyrimidine scaffolds undergo intramolecular cyclization reactions to form 1,3-diazepines and imidazopurines. / Lebedyeva, Iryna Oleksandrivna; Povstyanoy, V'Yacheslav M.; Ryabitskii, Aleksey B.; Panasyuk, Oleksandr; Ivahnenko, Evgen; Lozova, Vera P.; Markevich, Igor; Allakhverdova, Svitlana; Povstyanoy, Mykhaylo V.

In: European Journal of Organic Chemistry, No. 21, 01.07.2013, p. 4594-4606.

Research output: Contribution to journalArticle

Lebedyeva, IO, Povstyanoy, VYM, Ryabitskii, AB, Panasyuk, O, Ivahnenko, E, Lozova, VP, Markevich, I, Allakhverdova, S & Povstyanoy, MV 2013, 'Theophyllinylpyrimidine scaffolds undergo intramolecular cyclization reactions to form 1,3-diazepines and imidazopurines', European Journal of Organic Chemistry, no. 21, pp. 4594-4606. https://doi.org/10.1002/ejoc.201300360
Lebedyeva, Iryna Oleksandrivna ; Povstyanoy, V'Yacheslav M. ; Ryabitskii, Aleksey B. ; Panasyuk, Oleksandr ; Ivahnenko, Evgen ; Lozova, Vera P. ; Markevich, Igor ; Allakhverdova, Svitlana ; Povstyanoy, Mykhaylo V. / Theophyllinylpyrimidine scaffolds undergo intramolecular cyclization reactions to form 1,3-diazepines and imidazopurines. In: European Journal of Organic Chemistry. 2013 ; No. 21. pp. 4594-4606.
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AU - Ivahnenko, Evgen

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