TY - JOUR
T1 - Theophyllinylpyrimidine scaffolds undergo intramolecular cyclization reactions to form 1,3-diazepines and imidazopurines
AU - Lebedyeva, Iryna O.
AU - Povstyanoy, V'Yacheslav M.
AU - Ryabitskii, Aleksey B.
AU - Panasyuk, Oleksandr
AU - Ivahnenko, Evgen
AU - Lozova, Vera P.
AU - Markevich, Igor
AU - Allakhverdova, Svitlana
AU - Povstyanoy, Mykhaylo V.
PY - 2013/7
Y1 - 2013/7
N2 - Polyheterocyclic pyrimidinyltheophyllines have been synthesized from pyrimidine and theophylline precursors. Attempts to cyclize these reactive bis-heterocyclic systems resulted in the formation of the corresponding diazepine moieties. In addition, modification of the reaction conditions led to the formation of imidazo[2,1-f]purines. Polyheterocyclic pyrimidinyltheophyllines have been synthesized from pyrimidine and theophylline precursors. Attempts to cyclize these reactive bis-heterocyclic systems resulted in the formation of the diazepine moiety. Modification of the reaction conditions led to the formation of imidazo[2,1-f]purines.
AB - Polyheterocyclic pyrimidinyltheophyllines have been synthesized from pyrimidine and theophylline precursors. Attempts to cyclize these reactive bis-heterocyclic systems resulted in the formation of the corresponding diazepine moieties. In addition, modification of the reaction conditions led to the formation of imidazo[2,1-f]purines. Polyheterocyclic pyrimidinyltheophyllines have been synthesized from pyrimidine and theophylline precursors. Attempts to cyclize these reactive bis-heterocyclic systems resulted in the formation of the diazepine moiety. Modification of the reaction conditions led to the formation of imidazo[2,1-f]purines.
KW - Alkaloids
KW - Cyclization
KW - Fused-ring systems
KW - Medicinal chemistry
KW - Nitrogen heterocycles
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U2 - 10.1002/ejoc.201300360
DO - 10.1002/ejoc.201300360
M3 - Article
AN - SCOPUS:84880042374
SN - 1434-193X
SP - 4594
EP - 4606
JO - European Journal of Organic Chemistry
JF - European Journal of Organic Chemistry
IS - 21
ER -