Therapeutic effect of diltiazem on myocardial cell injury during the calcium paradox

M. Ashraf; M. Onda; Y. Hirohata; A. Schwartz

doi:10.1016/0022-2828(82)90247-4

Therapeutic effect of diltiazem on myocardial cell injury during the calcium paradox

M. Ashraf, M. Onda, Y. Hirohata, A. Schwartz

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

The calcium paradox induced massive structural damage to the sarcolemma and gap junctions. Treatment of these hearts with diltiazem, a calcium channel blocking agent, significantly prevented cell separation and rupture, gap junction alterations, and preserved tissue high energy phosphate content. It is suggested that the calcium paradoxical injury may be prevented with calcium channel blocking agents by maintaining the structural integrity of junctional sarcolemma and its components.

Original language	English (US)
Pages (from-to)	323-327
Number of pages	5
Journal	Journal of molecular and cellular cardiology
Volume	14
Issue number	6
DOIs	https://doi.org/10.1016/0022-2828(82)90247-4
State	Published - Jun 1982
Externally published	Yes

Keywords

Calcium paradox
Cell membrane
Cell separation
Diltiazem
Freeze fracture
Gap junction

ASJC Scopus subject areas

Molecular Biology
Cardiology and Cardiovascular Medicine

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10.1016/0022-2828(82)90247-4

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abstract = "The calcium paradox induced massive structural damage to the sarcolemma and gap junctions. Treatment of these hearts with diltiazem, a calcium channel blocking agent, significantly prevented cell separation and rupture, gap junction alterations, and preserved tissue high energy phosphate content. It is suggested that the calcium paradoxical injury may be prevented with calcium channel blocking agents by maintaining the structural integrity of junctional sarcolemma and its components.",

keywords = "Calcium paradox, Cell membrane, Cell separation, Diltiazem, Freeze fracture, Gap junction",

author = "M. Ashraf and M. Onda and Y. Hirohata and A. Schwartz",

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AU - Ashraf, M.

AU - Onda, M.

AU - Hirohata, Y.

AU - Schwartz, A.

N1 - Funding Information: Supported by NIH help of Joyce Turner

PY - 1982/6

Y1 - 1982/6

N2 - The calcium paradox induced massive structural damage to the sarcolemma and gap junctions. Treatment of these hearts with diltiazem, a calcium channel blocking agent, significantly prevented cell separation and rupture, gap junction alterations, and preserved tissue high energy phosphate content. It is suggested that the calcium paradoxical injury may be prevented with calcium channel blocking agents by maintaining the structural integrity of junctional sarcolemma and its components.

AB - The calcium paradox induced massive structural damage to the sarcolemma and gap junctions. Treatment of these hearts with diltiazem, a calcium channel blocking agent, significantly prevented cell separation and rupture, gap junction alterations, and preserved tissue high energy phosphate content. It is suggested that the calcium paradoxical injury may be prevented with calcium channel blocking agents by maintaining the structural integrity of junctional sarcolemma and its components.

KW - Calcium paradox

KW - Cell membrane

KW - Cell separation

KW - Diltiazem

KW - Freeze fracture

KW - Gap junction

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ER -

Therapeutic effect of diltiazem on myocardial cell injury during the calcium paradox

Abstract

Keywords

ASJC Scopus subject areas

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