Therapeutic effect of diltiazem on myocardial cell injury during the calcium paradox

M. Ashraf, M. Onda, Y. Hirohata, A. Schwartz

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

The calcium paradox induced massive structural damage to the sarcolemma and gap junctions. Treatment of these hearts with diltiazem, a calcium channel blocking agent, significantly prevented cell separation and rupture, gap junction alterations, and preserved tissue high energy phosphate content. It is suggested that the calcium paradoxical injury may be prevented with calcium channel blocking agents by maintaining the structural integrity of junctional sarcolemma and its components.

Original languageEnglish (US)
Pages (from-to)323-327
Number of pages5
JournalJournal of molecular and cellular cardiology
Volume14
Issue number6
DOIs
StatePublished - Jun 1982
Externally publishedYes

Keywords

  • Calcium paradox
  • Cell membrane
  • Cell separation
  • Diltiazem
  • Freeze fracture
  • Gap junction

ASJC Scopus subject areas

  • Molecular Biology
  • Cardiology and Cardiovascular Medicine

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