Therapeutic potential of annexin a1 modulation in kidney and cardiovascular disorders

Research output: Contribution to journalReview articlepeer-review

Abstract

Renal and cardiovascular disorders are very prevalent and associated with significant morbidity and mortality. Among diverse pathogenic mechanisms, the dysregulation of immune and inflammatory responses plays an essential role in such disorders. Consequently, the discovery of Annexin A1, as a glucocorticoid-inducible anti-inflammatory protein, has fueled investigation of its role in renal and cardiovascular pathologies. Indeed, with respect to the kidney, its role has been examined in diverse renal pathologies, including acute kidney injury, diabetic nephropathy, immune-mediated nephropathy, drug-induced kidney injury, kidney stone formation, and renal cancer. Regarding the cardiovascular system, major areas of investigation include the role of Annexin A1 in vascular abnormalities, atherosclerosis, and myocardial infarction. Thus, this review briefly describes major structural and functional features of Annexin A1 followed by a review of its role in pathologies of the kidney and the cardiovascular system, as well as the therapeutic potential of its modulation for such disorders.

Original languageEnglish (US)
Article number3420
JournalCells
Volume10
Issue number12
DOIs
StatePublished - Dec 2021

Keywords

  • Acute kidney injury
  • Annexins
  • Atherosclerosis
  • Cardiovascular system
  • Glomerulonephritis
  • Inflammation
  • Kidney
  • Kidney stone
  • Myocardial infarction
  • Nephropathy
  • Renal cancer

ASJC Scopus subject areas

  • Medicine(all)

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