Three properties of SARS-CoV-2 that promote COVID-19

Ken S. Rosenthal

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Much of COVID-19 disease can be attributed to the stable structure of the envelope, which facilitates its transmission; the spike protein and its receptor which determine which tissues get infected and are susceptible to viral and immune cytolysis; and evasion of initiation of type 1 and 3 interferons, which gives the virus a replicative head start and ability to spread while simultaneously compromising the antiviral immune response.

Original languageEnglish (US)
Pages (from-to)324-326
Number of pages3
JournalInfectious Diseases in Clinical Practice
Volume28
Issue number6
DOIs
StatePublished - Nov 1 2020
Externally publishedYes

Keywords

  • COVID-19
  • SARS CoV-2
  • type 1 interferon
  • type 3 interferon

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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