Thymoquinone Inhibits Autophagy and Induces Cathepsin-Mediated, Caspase-Independent Cell Death in Glioblastoma Cells

Agriculture & Biology

• glioblastoma 94%
• cathepsins 86%
• caspases 83%
• autophagy 77%
• cell death 60%
• apoptosis 29%
• cathepsin B 28%
• lysosomes 22%
• cells 20%
• brain neoplasms 16%
• cancer therapy 15%
• Nigella sativa 14%
• chloroquine 13%
• acridine orange 13%
• astrocytes 13%
• DNA fragmentation 12%
• seed oils 11%
• oxidants 10%
• microtubules 10%
• bioactive compounds 10%
• cytosol 10%
• neoplasm cells 9%
• cell proliferation 9%
• species recruitment 9%
• phytochemicals 9%
• mechanism of action 9%
• cytotoxicity 9%
• therapeutics 8%
• neoplasms 8%
• protein synthesis 8%
• pretreatment 8%
• staining 8%
• proteins 7%

Medicine & Life Sciences

• thymoquinone 100%
• Cathepsins 87%
• Caspases 65%
• Glioblastoma 64%
• Autophagy 62%
• Cell Death 49%
• Cathepsin B 18%
• Lysosomes 14%
• Apoptosis 13%
• caraway oil 12%
• Acridine Orange 9%
• Beclin-1 9%
• Caspase Inhibitors 8%
• Membranes 8%
• Microtubule-Associated Proteins 8%
• Chloroquine 8%
• Annexin A5 8%
• Survival 8%
• Phytochemicals 7%
• DNA Fragmentation 7%
• Neoplasms 7%
• Cytosol 6%
• Brain Neoplasms 6%
• Astrocytes 6%
• Veins 6%
• Therapeutics 5%
• Antioxidants 5%
• Anti-Inflammatory Agents 5%
• Light 5%
• Cell Proliferation 4%
• Staining and Labeling 4%
• Proteins 2%

Chemical Compounds

• Autophagy Inhibitor 82%
• Cell Death 69%
• Cathepsin B Inhibitor 39%
• P62 36%
• Antineoplastic 28%
• Chloroquine 28%
• Acridine Orange 27%
• Protein 26%
• Antiinflammatory 20%
• Fragmentation 17%
• Antioxidant Agent 16%
• Red 14%