Thyroid hormone influence on the susceptibility of mice to audiogenic seizures

Thomas N. Seyfried, Gilbert H. Glaser, Robert K. Yu

Research output: Contribution to journalArticle

58 Scopus citations

Abstract

Serum thyroxine levels peak earlier and are significantly higher in audiogenic seizure-susceptible DBA/2J mice than in seizure-resistant C57BL/6J mice during early postnatal life. The seizure susceptibility of DBA/2J mice is suppressed by administration of an antithyroid drug or by radiothyroidectomy, while the seizure susceptibility of C57BL/6J mice is enchanced by treatment with excess thyroxine.

Original languageEnglish (US)
Pages (from-to)598-600
Number of pages3
JournalScience
Volume205
Issue number4406
DOIs
StatePublished - Jan 1 1979
Externally publishedYes

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