Abstract
The adenovirus E2 promoter-binding factor-1 (E2F1) induces apoptosis in response to DNA damage and serum starvation. After DNA damage, E2F1 is phosphorylated by ataxia telangiectasia-mutated (ATM) kinase to promote apoptosis. However, precisely how serum starvation stimulates E2F1-induced apoptosis is unclear. We recently found that serum starvation reduces E2F1 poly(ADP-ribosyl)ation, thereby releasing a proapoptotic protein, bridging integrator-1 (BIN1), into the cytoplasm.
Original language | English (US) |
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Article number | e981447 |
Journal | Molecular and Cellular Oncology |
Volume | 2 |
Issue number | 2 |
DOIs | |
State | Published - Apr 3 2015 |
Keywords
- BIN1
- E2F1
- PARP1
- apoptosis
- cell cycle
- serum starvation
ASJC Scopus subject areas
- Molecular Medicine
- Cancer Research