To die, or not to die: E2F1 never decides by itself during serum starvation

Daitoku Sakamuro, Watson P. Folk, Alpana Kumari

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

The adenovirus E2 promoter-binding factor-1 (E2F1) induces apoptosis in response to DNA damage and serum starvation. After DNA damage, E2F1 is phosphorylated by ataxia telangiectasia-mutated (ATM) kinase to promote apoptosis. However, precisely how serum starvation stimulates E2F1-induced apoptosis is unclear. We recently found that serum starvation reduces E2F1 poly(ADP-ribosyl)ation, thereby releasing a proapoptotic protein, bridging integrator-1 (BIN1), into the cytoplasm.

Original languageEnglish (US)
Article numbere981447
JournalMolecular and Cellular Oncology
Volume2
Issue number2
DOIs
StatePublished - Apr 3 2015

Keywords

  • BIN1
  • E2F1
  • PARP1
  • apoptosis
  • cell cycle
  • serum starvation

ASJC Scopus subject areas

  • Molecular Medicine
  • Cancer Research

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