To die, or not to die: E2F1 never decides by itself during serum starvation

Daitoku Sakamuro, Watson P. Folk, Alpana Kumari

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The adenovirus E2 promoter-binding factor-1 (E2F1) induces apoptosis in response to DNA damage and serum starvation. After DNA damage, E2F1 is phosphorylated by ataxia telangiectasia-mutated (ATM) kinase to promote apoptosis. However, precisely how serum starvation stimulates E2F1-induced apoptosis is unclear. We recently found that serum starvation reduces E2F1 poly(ADP-ribosyl)ation, thereby releasing a proapoptotic protein, bridging integrator-1 (BIN1), into the cytoplasm.

Original languageEnglish (US)
Article numbere981447
JournalMolecular and Cellular Oncology
Volume2
Issue number2
DOIs
StatePublished - Apr 3 2015

Fingerprint

Starvation
Apoptosis
DNA Damage
Serum
Ataxia Telangiectasia
Adenoviridae
Adenosine Diphosphate
Cytoplasm
Phosphotransferases
Proteins

Keywords

  • BIN1
  • E2F1
  • PARP1
  • apoptosis
  • cell cycle
  • serum starvation

ASJC Scopus subject areas

  • Molecular Medicine
  • Cancer Research

Cite this

To die, or not to die : E2F1 never decides by itself during serum starvation. / Sakamuro, Daitoku; Folk, Watson P.; Kumari, Alpana.

In: Molecular and Cellular Oncology, Vol. 2, No. 2, e981447, 03.04.2015.

Research output: Contribution to journalArticle

@article{186111adda4d40e2bf4fb23de31005b7,
title = "To die, or not to die: E2F1 never decides by itself during serum starvation",
abstract = "The adenovirus E2 promoter-binding factor-1 (E2F1) induces apoptosis in response to DNA damage and serum starvation. After DNA damage, E2F1 is phosphorylated by ataxia telangiectasia-mutated (ATM) kinase to promote apoptosis. However, precisely how serum starvation stimulates E2F1-induced apoptosis is unclear. We recently found that serum starvation reduces E2F1 poly(ADP-ribosyl)ation, thereby releasing a proapoptotic protein, bridging integrator-1 (BIN1), into the cytoplasm.",
keywords = "BIN1, E2F1, PARP1, apoptosis, cell cycle, serum starvation",
author = "Daitoku Sakamuro and Folk, {Watson P.} and Alpana Kumari",
year = "2015",
month = "4",
day = "3",
doi = "10.4161/23723556.2014.981447",
language = "English (US)",
volume = "2",
journal = "Molecular and Cellular Oncology",
issn = "2372-3556",
publisher = "Taylor and Francis Ltd.",
number = "2",

}

TY - JOUR

T1 - To die, or not to die

T2 - E2F1 never decides by itself during serum starvation

AU - Sakamuro, Daitoku

AU - Folk, Watson P.

AU - Kumari, Alpana

PY - 2015/4/3

Y1 - 2015/4/3

N2 - The adenovirus E2 promoter-binding factor-1 (E2F1) induces apoptosis in response to DNA damage and serum starvation. After DNA damage, E2F1 is phosphorylated by ataxia telangiectasia-mutated (ATM) kinase to promote apoptosis. However, precisely how serum starvation stimulates E2F1-induced apoptosis is unclear. We recently found that serum starvation reduces E2F1 poly(ADP-ribosyl)ation, thereby releasing a proapoptotic protein, bridging integrator-1 (BIN1), into the cytoplasm.

AB - The adenovirus E2 promoter-binding factor-1 (E2F1) induces apoptosis in response to DNA damage and serum starvation. After DNA damage, E2F1 is phosphorylated by ataxia telangiectasia-mutated (ATM) kinase to promote apoptosis. However, precisely how serum starvation stimulates E2F1-induced apoptosis is unclear. We recently found that serum starvation reduces E2F1 poly(ADP-ribosyl)ation, thereby releasing a proapoptotic protein, bridging integrator-1 (BIN1), into the cytoplasm.

KW - BIN1

KW - E2F1

KW - PARP1

KW - apoptosis

KW - cell cycle

KW - serum starvation

UR - http://www.scopus.com/inward/record.url?scp=85020154367&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85020154367&partnerID=8YFLogxK

U2 - 10.4161/23723556.2014.981447

DO - 10.4161/23723556.2014.981447

M3 - Article

AN - SCOPUS:85020154367

VL - 2

JO - Molecular and Cellular Oncology

JF - Molecular and Cellular Oncology

SN - 2372-3556

IS - 2

M1 - e981447

ER -