Toll-like receptors in the vascular system: Sensing the dangers within

Styliani Goulopoulou, Cameron G. McCarthy, R. Clinton Webb

Research output: Contribution to journalArticle

86 Scopus citations

Abstract

Toll-like receptors (TLRs) are components of the innate immune system that respond to exogenous infectious ligands (pathogen-associated molecular patterns, PAMPs) and endogenous molecules that are released during host tissue injury/death (damageassociated molecular patterns, DAMPs). Interaction of TLRs with their ligands leads to activation of downstream signaling pathways that induce an immune response by producing inflammatory cytokines, type Iinterferons (IFN), and other inflammatory mediators. TLRactivation affects vascular function and remodeling,0 and these molecular events prime antigen-specific.

Original languageEnglish (US)
Pages (from-to)142-167
Number of pages26
JournalPharmacological Reviews
Volume68
Issue number1
DOIs
StatePublished - 2016

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

Fingerprint Dive into the research topics of 'Toll-like receptors in the vascular system: Sensing the dangers within'. Together they form a unique fingerprint.

  • Cite this