Toll-like receptors in the vascular system: Sensing the dangers within

Styliani Goulopoulou, Cameron G. McCarthy, R. Clinton Webb

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

Toll-like receptors (TLRs) are components of the innate immune system that respond to exogenous infectious ligands (pathogen-associated molecular patterns, PAMPs) and endogenous molecules that are released during host tissue injury/death (damageassociated molecular patterns, DAMPs). Interaction of TLRs with their ligands leads to activation of downstream signaling pathways that induce an immune response by producing inflammatory cytokines, type Iinterferons (IFN), and other inflammatory mediators. TLRactivation affects vascular function and remodeling,0 and these molecular events prime antigen-specific.

Original languageEnglish (US)
Pages (from-to)142-167
Number of pages26
JournalPharmacological Reviews
Volume68
Issue number1
DOIs
StatePublished - Jan 1 2016

Fingerprint

Toll-Like Receptors
Blood Vessels
Ligands
Immune System
Cytokines
Antigens
Wounds and Injuries
Pathogen-Associated Molecular Pattern Molecules
Vascular Remodeling

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

Cite this

Toll-like receptors in the vascular system : Sensing the dangers within. / Goulopoulou, Styliani; McCarthy, Cameron G.; Clinton Webb, R.

In: Pharmacological Reviews, Vol. 68, No. 1, 01.01.2016, p. 142-167.

Research output: Contribution to journalArticle

Goulopoulou, Styliani ; McCarthy, Cameron G. ; Clinton Webb, R. / Toll-like receptors in the vascular system : Sensing the dangers within. In: Pharmacological Reviews. 2016 ; Vol. 68, No. 1. pp. 142-167.
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