Topical application of a Rho-kinase inhibitor in rats causes penile erection

Y. Dai, K. Chitaley, R. C. Webb, R. W. Lewis, T. M. Mills

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Studies from this laboratory have demonstrated that RhoA/Rho-kinase signaling mediates vasoconstriction in the penile circulation of the rat and that erection results from inhibition of this activity with Y-27632. In prior animal studies, Y-27632 was administered to the rats by intracavernous injection. To determine if topical application of the Rho-kinase inhibitor is an effective mode of delivery, Y-27632 was applied to the surface of the tunica albuginea or to the glans penis and surrounding skin in intact or castrated rats. Both sites of drug administration resulted in a marked increase in the erectile response both with and without stimulation of the autonomic innervation of the penile vasculature. Although high doses of the drug were found to reduce systemic blood pressure, topical administration of the Rho-kinase inhibitor, in appropriate doses, may have clinical value for the treatment erectile dysfunction.

Original languageEnglish (US)
Pages (from-to)294-298
Number of pages5
JournalInternational journal of impotence research
Volume16
Issue number3
DOIs
StatePublished - Jun 1 2004

Fingerprint

Penile Erection
rho-Associated Kinases
Topical Administration
Penis
Erectile Dysfunction
Vasoconstriction
Pharmaceutical Preparations
Blood Pressure
Skin
Injections
Y 27632
Therapeutics

Keywords

  • Erectile response
  • Rat
  • Rho-kinase
  • RhoA
  • Topical drug application

ASJC Scopus subject areas

  • Urology

Cite this

Topical application of a Rho-kinase inhibitor in rats causes penile erection. / Dai, Y.; Chitaley, K.; Webb, R. C.; Lewis, R. W.; Mills, T. M.

In: International journal of impotence research, Vol. 16, No. 3, 01.06.2004, p. 294-298.

Research output: Contribution to journalArticle

Dai, Y. ; Chitaley, K. ; Webb, R. C. ; Lewis, R. W. ; Mills, T. M. / Topical application of a Rho-kinase inhibitor in rats causes penile erection. In: International journal of impotence research. 2004 ; Vol. 16, No. 3. pp. 294-298.
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