Towards Transgenic Primates: What can we learn from mouse genetics?

Research output: Contribution to journalReview article

5 Citations (Scopus)

Abstract

Considering the great physiological and behavioral similarities with humans, monkeys represent the ideal models not only for the study of complex cognitive behavior but also for the preclinical research and development of novel therapeutics for treating human diseases. Various powerful genetic technologies initially developed for making mouse models are being explored for generating transgenic primate models. We review the latest genetic engineering technologies and discuss the potentials and limitations for systematic production of transgenic primates.

Original languageEnglish (US)
Pages (from-to)506-514
Number of pages9
JournalScience in China, Series C: Life Sciences
Volume52
Issue number6
DOIs
StatePublished - Apr 1 2009

Fingerprint

primate
Primates
animal models
genetically modified organisms
Technology
Genetic Engineering
mice
research and development
genetic engineering
human diseases
Haplorhini
monkeys
Genetic engineering
Engineering technology
therapeutics
Research
Genetics
Therapeutics
human disease

Keywords

  • Disease model
  • Genetics
  • Learning
  • Memory
  • Mouse
  • Non-human primate
  • Transgene

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Environmental Science(all)

Cite this

Towards Transgenic Primates : What can we learn from mouse genetics? / Kuang, Hui; Wang, Lei; Tsien, Joseph Zhuo.

In: Science in China, Series C: Life Sciences, Vol. 52, No. 6, 01.04.2009, p. 506-514.

Research output: Contribution to journalReview article

@article{51ca1c70157c4e5997dd314e0cb4824b,
title = "Towards Transgenic Primates: What can we learn from mouse genetics?",
abstract = "Considering the great physiological and behavioral similarities with humans, monkeys represent the ideal models not only for the study of complex cognitive behavior but also for the preclinical research and development of novel therapeutics for treating human diseases. Various powerful genetic technologies initially developed for making mouse models are being explored for generating transgenic primate models. We review the latest genetic engineering technologies and discuss the potentials and limitations for systematic production of transgenic primates.",
keywords = "Disease model, Genetics, Learning, Memory, Mouse, Non-human primate, Transgene",
author = "Hui Kuang and Lei Wang and Tsien, {Joseph Zhuo}",
year = "2009",
month = "4",
day = "1",
doi = "10.1007/s11427-009-0082-8",
language = "English (US)",
volume = "52",
pages = "506--514",
journal = "Science in China, Series C: Life Sciences",
issn = "1006-9305",
publisher = "Science in China Press",
number = "6",

}

TY - JOUR

T1 - Towards Transgenic Primates

T2 - What can we learn from mouse genetics?

AU - Kuang, Hui

AU - Wang, Lei

AU - Tsien, Joseph Zhuo

PY - 2009/4/1

Y1 - 2009/4/1

N2 - Considering the great physiological and behavioral similarities with humans, monkeys represent the ideal models not only for the study of complex cognitive behavior but also for the preclinical research and development of novel therapeutics for treating human diseases. Various powerful genetic technologies initially developed for making mouse models are being explored for generating transgenic primate models. We review the latest genetic engineering technologies and discuss the potentials and limitations for systematic production of transgenic primates.

AB - Considering the great physiological and behavioral similarities with humans, monkeys represent the ideal models not only for the study of complex cognitive behavior but also for the preclinical research and development of novel therapeutics for treating human diseases. Various powerful genetic technologies initially developed for making mouse models are being explored for generating transgenic primate models. We review the latest genetic engineering technologies and discuss the potentials and limitations for systematic production of transgenic primates.

KW - Disease model

KW - Genetics

KW - Learning

KW - Memory

KW - Mouse

KW - Non-human primate

KW - Transgene

UR - http://www.scopus.com/inward/record.url?scp=70149100904&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=70149100904&partnerID=8YFLogxK

U2 - 10.1007/s11427-009-0082-8

DO - 10.1007/s11427-009-0082-8

M3 - Review article

C2 - 19557327

AN - SCOPUS:70149100904

VL - 52

SP - 506

EP - 514

JO - Science in China, Series C: Life Sciences

JF - Science in China, Series C: Life Sciences

SN - 1006-9305

IS - 6

ER -