Towards Transgenic Primates: What can we learn from mouse genetics?

Hui Kuang, Phillip L. Wang, Joe Z. Tsien

Research output: Contribution to journalReview article

5 Scopus citations

Abstract

Considering the great physiological and behavioral similarities with humans, monkeys represent the ideal models not only for the study of complex cognitive behavior but also for the preclinical research and development of novel therapeutics for treating human diseases. Various powerful genetic technologies initially developed for making mouse models are being explored for generating transgenic primate models. We review the latest genetic engineering technologies and discuss the potentials and limitations for systematic production of transgenic primates.

Original languageEnglish (US)
Pages (from-to)506-514
Number of pages9
JournalScience in China, Series C: Life Sciences
Volume52
Issue number6
DOIs
StatePublished - Apr 1 2009

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Keywords

  • Disease model
  • Genetics
  • Learning
  • Memory
  • Mouse
  • Non-human primate
  • Transgene

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Environmental Science(all)
  • Agricultural and Biological Sciences(all)

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