Abstract
Background: Roles of SoxC genes in the development of retinal ganglion cells (RGCs) are unknown at present. Results: Targeted deletion of Sox4 and Sox11 in retina results in a complete loss of RGCs. Conclusion: Sox4 and Sox11 function redundantly to regulate RGC development. Significance: These findings highlight the essential role of SoxC genes in retinal development.
Original language | English (US) |
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Pages (from-to) | 18429-18438 |
Number of pages | 10 |
Journal | Journal of Biological Chemistry |
Volume | 288 |
Issue number | 25 |
DOIs | |
State | Published - Jun 21 2013 |
Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology