Background: Roles of SoxC genes in the development of retinal ganglion cells (RGCs) are unknown at present. Results: Targeted deletion of Sox4 and Sox11 in retina results in a complete loss of RGCs. Conclusion: Sox4 and Sox11 function redundantly to regulate RGC development. Significance: These findings highlight the essential role of SoxC genes in retinal development.
|Original language||English (US)|
|Number of pages||10|
|Journal||Journal of Biological Chemistry|
|State||Published - Jun 21 2013|
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology