Transcription factors SOX4 and SOX11 function redundantly to regulate the development of mouse retinal ganglion cells

Ying Jiang, Qian Ding, Xiaoling Xie, Richard T. Libby, Veronique Lefebvre, Lin Gan

Research output: Contribution to journalArticle

62 Scopus citations

Abstract

Background: Roles of SoxC genes in the development of retinal ganglion cells (RGCs) are unknown at present. Results: Targeted deletion of Sox4 and Sox11 in retina results in a complete loss of RGCs. Conclusion: Sox4 and Sox11 function redundantly to regulate RGC development. Significance: These findings highlight the essential role of SoxC genes in retinal development.

Original languageEnglish (US)
Pages (from-to)18429-18438
Number of pages10
JournalJournal of Biological Chemistry
Volume288
Issue number25
DOIs
StatePublished - Jun 21 2013
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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