Transforming growth factor β1 dysregulation in a human oral carcinoma tumour progression model

S. Hsu, J. L. Borke, J. B. Lewis, B. Singh, A. C. Aiken, C. T. Huynh, G. S. Schuster, G. B. Caughman, D. P. Dickinson, A. K. Smith, T. Osaki, X. F. Wang

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10 Scopus citations

Abstract

A human oral tumour progression model was established that consists of normal epithelial cells and three cell lines representing stages from dysplastic to metastatic cells. To investigate the impact of exogenous transforming growth factor-β1 on this model system, we analysed the responsiveness of those cells to transforming growth factor-β1 and explored the potential mechanism underlying the transforming growth factor-β1 activity. We found that the growth of all cell types, regardless of their stage of tumour progression, is inhibited by transforming growth factor-β1, although to different degrees. Transforming growth factor-β1 induced the expression of cyclin-dependent kinase inhibitors p15INK4B, p21WAF1/CIP1 and p27KIP1. In contrast, transforming growth factor-β1 was found to stimulate the invasive potential of one cell type that represents the most advanced stage of tumour phenotype, suggesting that the impact of transforming growth factor-β1 on functional features of tumour cells other than cellular proliferation may play a significant role in the process of oral tumour progression.

Original languageEnglish (US)
Pages (from-to)183-192
Number of pages10
JournalCell Proliferation
Volume35
Issue number3
DOIs
StatePublished - May 30 2002

ASJC Scopus subject areas

  • Cell Biology

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    Hsu, S., Borke, J. L., Lewis, J. B., Singh, B., Aiken, A. C., Huynh, C. T., Schuster, G. S., Caughman, G. B., Dickinson, D. P., Smith, A. K., Osaki, T., & Wang, X. F. (2002). Transforming growth factor β1 dysregulation in a human oral carcinoma tumour progression model. Cell Proliferation, 35(3), 183-192. https://doi.org/10.1046/j.1365-2184.2002.00237.x