Translocation t(1;19)(q23;p13) in adult acute lymphoblastic leukemia–a distinct subtype with favorable prognosis

Musa Yilmaz, Hagop M. Kantarjian, Gokce Toruner, C. Cameron Yin, Rashmi Kanagal-Shamanna, Jorge E. Cortes, Ghayyas Issa, Nicholas J. Short, Joseph D. Khoury, Guillermo Garcia-Manero, Farhad Ravandi, Tapan Kadia, Marina Konopleva, William G. Wierda, Nitin Jain, Zeev Estrov, Koji Sasaki, Sherry Pierce, Susan M. O'Brien, Elias J. Jabbour

Research output: Contribution to journalArticle

Abstract

The recurring translocation t(1;19) (q23;p13) with TCF3-PBX1 rearrangements are uncommon in adult acute lymphoblastic leukemia (ALL), and their prognostic impact remains to be described in the era of modern chemotherapies. We investigated 427 adult patients with newly diagnosed pre-B ALL, 16 (4%) had t(1;19)(q23;p13) at diagnosis. All 16 patients achieved complete remission after induction with intensive chemotherapy, and with a median of 7-year follow-up, 2 relapsed. The 5-year cumulative incidence of relapse and overall survival rates were 14% and 82%, respectively. Our analysis showed that adult patients with t(1;19)(q23;p13) positive ALL had favorable prognosis with intensive chemotherapy regimens.

Original languageEnglish (US)
JournalLeukemia and Lymphoma
DOIs
StateAccepted/In press - 2020

Keywords

  • )
  • ALL
  • TCF3-PBX1
  • outcome
  • prognosis
  • t(1;19

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'Translocation t(1;19)(q23;p13) in adult acute lymphoblastic leukemia–a distinct subtype with favorable prognosis'. Together they form a unique fingerprint.

Cite this