Transplantation of carotid body cells in the treatment of neurological disorders

Guolong Yu, Christina Fournier, David C Hess, Cesar V. Borlongan

Research output: Contribution to journalReview article

10 Citations (Scopus)

Abstract

Laboratory and clinical studies have shown that intracerebral transplantation of carotid body (CB) cells ameliorate Parkinsonian deficits. The recent clinical study by Arjona and colleagues indicated that CB autograft transplantation is a relatively simple, safe, and viable treatment for PD patients. In particular, Espejo and colleagues demonstrated that the therapeutic efficacy of intracerebral transplantation of the CB in PD was likely obtained through secretion of neurotrophic factors rather than the local release of dopamine, which suggests it possible and reasonable to extend the use of the CB as an efficacious graft source for neural transplantation. Thus, we transplanted CB cell suspensions into the ischemic penumbra within 1 h after stroke surgery. The results revealed that CB transplantation also significantly reduced stroke-induced behavioral deficits and cerebral infarction. In this review, we focus on summarizing the physiological properties of the CB related to transplantation, describing briefly possible mechanisms responsible for the effect of CB transplantation, and introducing recent studies of the CB as a donor source for neural transplantation.

Original languageEnglish (US)
Pages (from-to)803-810
Number of pages8
JournalNeuroscience and Biobehavioral Reviews
Volume28
Issue number8
DOIs
StatePublished - Jan 1 2005

Fingerprint

Carotid Body
Nervous System Diseases
Transplantation
Therapeutics
Stroke
Cerebral Infarction
Autografts
Nerve Growth Factors
Dopamine
Suspensions
Tissue Donors
Transplants

Keywords

  • Carotid body
  • Neural transplantation
  • Neurological Disorders
  • Neurotrophic factors
  • Parkinson's disease
  • Stroke

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Cognitive Neuroscience
  • Behavioral Neuroscience

Cite this

Transplantation of carotid body cells in the treatment of neurological disorders. / Yu, Guolong; Fournier, Christina; Hess, David C; Borlongan, Cesar V.

In: Neuroscience and Biobehavioral Reviews, Vol. 28, No. 8, 01.01.2005, p. 803-810.

Research output: Contribution to journalReview article

Yu, Guolong ; Fournier, Christina ; Hess, David C ; Borlongan, Cesar V. / Transplantation of carotid body cells in the treatment of neurological disorders. In: Neuroscience and Biobehavioral Reviews. 2005 ; Vol. 28, No. 8. pp. 803-810.
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