Transporters and receptors for short-chain fatty acids as the molecular link between colonic bacteria and the host

Research output: Contribution to journalReview article

109 Scopus citations

Abstract

The mutually beneficial relationship between colonic bacteria and the host has been recognized but the molecular aspects of the relationship remain poorly understood. Dietary fiber is critical to this relationship. The short-chain fatty acids acetate, propionate and butyrate, generated by bacterial fermentation of dietary fiber, serve as messengers between colonic bacteria and the host. The beneficial effects of these bacterial metabolites in colon include, but are not limited to, suppression of inflammation and prevention of cancer. Recent studies have identified the plasma membrane transporter SLC5A8 and the cell-surface receptors GPR109A and GPR43 as essential for the biologic effects of short-chain fatty acids in colon. These three proteins coded by the host genome provide the molecular link between colonic bacteria and the host.

Original languageEnglish (US)
Pages (from-to)869-874
Number of pages6
JournalCurrent Opinion in Pharmacology
Volume13
Issue number6
DOIs
StatePublished - Jan 1 2013

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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