Treatment of allergic rhinitis with a new selective H1 antihistamine: terfenadine.

C. E. Buckley, S. J. Klemawesch, S. K. Lucas

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The effectiveness of 60 mg b.i.d. of a novel antihistamine, terfenadine, was compared with an active control, 4 mg t.i.d. of chlorpheniramine, and placebo in 560 patients with seasonal allergic rhinitis. In contrast to the gradual decrease in seasonal symptoms observed over a 7 day period of study in placebo-treated patients, both antihistamines produced a prompt significant decrease in sneezing and rhinorrhea, and a gradual decrease in nasopharyngeal pruritus. Terfenadine-related sedation did not differ from that produced by the placebo and was less than the sedation produced by the active control.

Original languageEnglish (US)
Pages (from-to)63-70
Number of pages8
JournalNew England and regional allergy proceedings
Volume6
Issue number1
StatePublished - Dec 1 1985

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Terfenadine
Histamine Antagonists
Placebos
Chlorpheniramine
Sneezing
Seasonal Allergic Rhinitis
Pruritus
Therapeutics
Allergic Rhinitis

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Treatment of allergic rhinitis with a new selective H1 antihistamine : terfenadine. / Buckley, C. E.; Klemawesch, S. J.; Lucas, S. K.

In: New England and regional allergy proceedings, Vol. 6, No. 1, 01.12.1985, p. 63-70.

Research output: Contribution to journalArticle

Buckley, C. E. ; Klemawesch, S. J. ; Lucas, S. K. / Treatment of allergic rhinitis with a new selective H1 antihistamine : terfenadine. In: New England and regional allergy proceedings. 1985 ; Vol. 6, No. 1. pp. 63-70.
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