Treatment of appendiceal adenocarcinoma in the United States

Penetration and outcomes of current guidelines

Kenneth C Walters, B. Lauren Paton, Thomas S. Schmelzer, Keith S. Gersin, David A. Iannitti, Kent W. Kercher, B. Todd Heniford

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Current treatment guidelines for appendiceal adenocarcinoma specify that right hemicolectomy should be performed. This study evaluates appendiceal cancer outcomes in the United States and treatment guideline compliance. Data for patients diagnosed with appendiceal adenocarcinoma in the Surveillance, Epidemiology, and End Results database (1988 to 2003) were analyzed. The 2511 patients with appendiceal adenocarcinoma had an average age of 59.3 years, average tumor size of 4.05 cm, and 5-year survival rate of 57 per cent. The 5-year survival rate by stage was statistically different (P < 0.001): Stage 0, 95.7 per cent; Stage I, 88 per cent; Stage II, 75.2 per cent; Stage III, 37.1 per cent; and Stage IV, 25.6 per cent. Appendectomy was performed in 33.4 per cent, which does not follow the current guidelines. In this group, 5-year survival was significantly less for patients with Stage III and IV disease (48% vs 38.2%, P = 0.03; 46% vs 26.4%, P = 0.04, respectively). Patients with Stage I and II disease had similar 5-year survival for appendectomy and colectomy (90.2% vs 90.1%, P = 0.7; 78.3% vs 76%, P = 0.6, respectively). One-third of patients with adenocarcinoma did not undergo current surgical guideline therapy. However, it appears hemicolectomy only improved survival for patients with later-stage disease. The current data raise the question of whether Stage I and II appendiceal cancer can be adequately treated with simple appendectomy.

Original languageEnglish (US)
Pages (from-to)1066-1068
Number of pages3
JournalAmerican Surgeon
Volume74
Issue number11
StatePublished - Nov 1 2008
Externally publishedYes

Fingerprint

Adenocarcinoma
Guidelines
Appendectomy
Appendiceal Neoplasms
Survival
Therapeutics
Survival Rate
Colectomy
Compliance
Epidemiology
Databases
Neoplasms

ASJC Scopus subject areas

  • Surgery

Cite this

Walters, K. C., Paton, B. L., Schmelzer, T. S., Gersin, K. S., Iannitti, D. A., Kercher, K. W., & Heniford, B. T. (2008). Treatment of appendiceal adenocarcinoma in the United States: Penetration and outcomes of current guidelines. American Surgeon, 74(11), 1066-1068.

Treatment of appendiceal adenocarcinoma in the United States : Penetration and outcomes of current guidelines. / Walters, Kenneth C; Paton, B. Lauren; Schmelzer, Thomas S.; Gersin, Keith S.; Iannitti, David A.; Kercher, Kent W.; Heniford, B. Todd.

In: American Surgeon, Vol. 74, No. 11, 01.11.2008, p. 1066-1068.

Research output: Contribution to journalArticle

Walters, KC, Paton, BL, Schmelzer, TS, Gersin, KS, Iannitti, DA, Kercher, KW & Heniford, BT 2008, 'Treatment of appendiceal adenocarcinoma in the United States: Penetration and outcomes of current guidelines', American Surgeon, vol. 74, no. 11, pp. 1066-1068.
Walters KC, Paton BL, Schmelzer TS, Gersin KS, Iannitti DA, Kercher KW et al. Treatment of appendiceal adenocarcinoma in the United States: Penetration and outcomes of current guidelines. American Surgeon. 2008 Nov 1;74(11):1066-1068.
Walters, Kenneth C ; Paton, B. Lauren ; Schmelzer, Thomas S. ; Gersin, Keith S. ; Iannitti, David A. ; Kercher, Kent W. ; Heniford, B. Todd. / Treatment of appendiceal adenocarcinoma in the United States : Penetration and outcomes of current guidelines. In: American Surgeon. 2008 ; Vol. 74, No. 11. pp. 1066-1068.
@article{12b38eeb498744898fbe6e27ca116bd1,
title = "Treatment of appendiceal adenocarcinoma in the United States: Penetration and outcomes of current guidelines",
abstract = "Current treatment guidelines for appendiceal adenocarcinoma specify that right hemicolectomy should be performed. This study evaluates appendiceal cancer outcomes in the United States and treatment guideline compliance. Data for patients diagnosed with appendiceal adenocarcinoma in the Surveillance, Epidemiology, and End Results database (1988 to 2003) were analyzed. The 2511 patients with appendiceal adenocarcinoma had an average age of 59.3 years, average tumor size of 4.05 cm, and 5-year survival rate of 57 per cent. The 5-year survival rate by stage was statistically different (P < 0.001): Stage 0, 95.7 per cent; Stage I, 88 per cent; Stage II, 75.2 per cent; Stage III, 37.1 per cent; and Stage IV, 25.6 per cent. Appendectomy was performed in 33.4 per cent, which does not follow the current guidelines. In this group, 5-year survival was significantly less for patients with Stage III and IV disease (48{\%} vs 38.2{\%}, P = 0.03; 46{\%} vs 26.4{\%}, P = 0.04, respectively). Patients with Stage I and II disease had similar 5-year survival for appendectomy and colectomy (90.2{\%} vs 90.1{\%}, P = 0.7; 78.3{\%} vs 76{\%}, P = 0.6, respectively). One-third of patients with adenocarcinoma did not undergo current surgical guideline therapy. However, it appears hemicolectomy only improved survival for patients with later-stage disease. The current data raise the question of whether Stage I and II appendiceal cancer can be adequately treated with simple appendectomy.",
author = "Walters, {Kenneth C} and Paton, {B. Lauren} and Schmelzer, {Thomas S.} and Gersin, {Keith S.} and Iannitti, {David A.} and Kercher, {Kent W.} and Heniford, {B. Todd}",
year = "2008",
month = "11",
day = "1",
language = "English (US)",
volume = "74",
pages = "1066--1068",
journal = "American Surgeon",
issn = "0003-1348",
publisher = "Southeastern Surgical Congress",
number = "11",

}

TY - JOUR

T1 - Treatment of appendiceal adenocarcinoma in the United States

T2 - Penetration and outcomes of current guidelines

AU - Walters, Kenneth C

AU - Paton, B. Lauren

AU - Schmelzer, Thomas S.

AU - Gersin, Keith S.

AU - Iannitti, David A.

AU - Kercher, Kent W.

AU - Heniford, B. Todd

PY - 2008/11/1

Y1 - 2008/11/1

N2 - Current treatment guidelines for appendiceal adenocarcinoma specify that right hemicolectomy should be performed. This study evaluates appendiceal cancer outcomes in the United States and treatment guideline compliance. Data for patients diagnosed with appendiceal adenocarcinoma in the Surveillance, Epidemiology, and End Results database (1988 to 2003) were analyzed. The 2511 patients with appendiceal adenocarcinoma had an average age of 59.3 years, average tumor size of 4.05 cm, and 5-year survival rate of 57 per cent. The 5-year survival rate by stage was statistically different (P < 0.001): Stage 0, 95.7 per cent; Stage I, 88 per cent; Stage II, 75.2 per cent; Stage III, 37.1 per cent; and Stage IV, 25.6 per cent. Appendectomy was performed in 33.4 per cent, which does not follow the current guidelines. In this group, 5-year survival was significantly less for patients with Stage III and IV disease (48% vs 38.2%, P = 0.03; 46% vs 26.4%, P = 0.04, respectively). Patients with Stage I and II disease had similar 5-year survival for appendectomy and colectomy (90.2% vs 90.1%, P = 0.7; 78.3% vs 76%, P = 0.6, respectively). One-third of patients with adenocarcinoma did not undergo current surgical guideline therapy. However, it appears hemicolectomy only improved survival for patients with later-stage disease. The current data raise the question of whether Stage I and II appendiceal cancer can be adequately treated with simple appendectomy.

AB - Current treatment guidelines for appendiceal adenocarcinoma specify that right hemicolectomy should be performed. This study evaluates appendiceal cancer outcomes in the United States and treatment guideline compliance. Data for patients diagnosed with appendiceal adenocarcinoma in the Surveillance, Epidemiology, and End Results database (1988 to 2003) were analyzed. The 2511 patients with appendiceal adenocarcinoma had an average age of 59.3 years, average tumor size of 4.05 cm, and 5-year survival rate of 57 per cent. The 5-year survival rate by stage was statistically different (P < 0.001): Stage 0, 95.7 per cent; Stage I, 88 per cent; Stage II, 75.2 per cent; Stage III, 37.1 per cent; and Stage IV, 25.6 per cent. Appendectomy was performed in 33.4 per cent, which does not follow the current guidelines. In this group, 5-year survival was significantly less for patients with Stage III and IV disease (48% vs 38.2%, P = 0.03; 46% vs 26.4%, P = 0.04, respectively). Patients with Stage I and II disease had similar 5-year survival for appendectomy and colectomy (90.2% vs 90.1%, P = 0.7; 78.3% vs 76%, P = 0.6, respectively). One-third of patients with adenocarcinoma did not undergo current surgical guideline therapy. However, it appears hemicolectomy only improved survival for patients with later-stage disease. The current data raise the question of whether Stage I and II appendiceal cancer can be adequately treated with simple appendectomy.

UR - http://www.scopus.com/inward/record.url?scp=58149385282&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=58149385282&partnerID=8YFLogxK

M3 - Article

VL - 74

SP - 1066

EP - 1068

JO - American Surgeon

JF - American Surgeon

SN - 0003-1348

IS - 11

ER -