Treatment of blastomycosis with higher doses of fluconazole

Peter G. Pappas, Robert W. Bradsher, Carol A. Kauffman, Gretchen A. Cloud, Carolynn J. Thomas, G. Douglas Campbell, Stanley W. Chapman, Cheryl L Newman, William E. Dismukes

Research output: Contribution to journalArticle

76 Scopus citations

Abstract

Recent clinical data suggest that fluconazole at daily doses of 200 to 400 mg for at least 6 months is moderately effective therapy for non-life- threatening blastomycosis. To examine the usefulness of higher doses of fluconazole therapy for this disorder, we conducted a multicenter, randomized, open-label study to determine the efficacy and safety of two different daily doses of fluconazole (400 and 800 mg) in the treatment of non-life-threatening blastomycosis. Of 39 patients evaluable for efficacy analysis, 34 (87%) were successfully treated, including 89% and 85% of patients who received 400 and 800 mg, respectively. Five (83%) of six patients for whom prior antifungal therapy had failed were successfully treated. The mean duration of therapy was 8.9 months for successfully treated patients. Nineteen patients (48%) reported adverse events, although most were minor. We conclude that fluconazole at daily doses of 400 to 800 mg for at least 6 months is effective therapy for non-life-threatening blastomycosis.

Original languageEnglish (US)
Pages (from-to)200-205
Number of pages6
JournalClinical Infectious Diseases
Volume25
Issue number2
DOIs
StatePublished - Jan 1 1997
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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    Pappas, P. G., Bradsher, R. W., Kauffman, C. A., Cloud, G. A., Thomas, C. J., Campbell, G. D., Chapman, S. W., Newman, C. L., & Dismukes, W. E. (1997). Treatment of blastomycosis with higher doses of fluconazole. Clinical Infectious Diseases, 25(2), 200-205. https://doi.org/10.1086/514539