Treatment of catheter-related bacteremia with tissue plasminogen activator antibiotic locks

Ali Mirza Onder, Jayanthi Chandar, Nancy Simon, Marie Saint-Vil, Denise Francoeur, Obioma Ikechukwu Nwobi, Carolyn Abitbol, Gaston Zilleruelo

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

This retrospective study was completed to investigate the effectiveness of tissue plasminogen activator (TPA) antibiotic locks (ABL) along with systemic antibiotics (AB) to clear catheter-related bacteremia (CRB) in children on chronic hemodialysis. There were 76 CRBs in 37 children. CRBs were successfully cleared with AB/ABL in 63/76 (83%) cases. Ten of 76 (13%) CRBs were symptomatic at 48 h of treatment. These were seven polymicrobial, two gram-negative, and one Candida CRB. 13/76 (17%) episodes required catheter exchange, and all were wire-guided exchanges. TPA-ABL/AB cleared gram-positive and gram-negative CRBs significantly better than polymicrobial CRBs (p<0.01). The infection-free survival and the rate of recurrence at 45 days was not statistically different between the TPA-ABL/AB group and the catheter-exchange group. If CRB was symptomatic at 48 h of treatment, recurrence at 6 weeks was more frequent with persistent use of TPA-ABL/AB (p<0.05). There were no episodes of metastatic infections, catheter malfunction from occlusion, or catheter breakdown during the course of TPA-ABL treatments. In conclusion, TPA-ABL can be safely and effectively used in the management of CRB, increasing the probability of catheter survival and preserving the vascular access site. With the exception of polymicrobial CRB, there is no disadvantage in using TPA-ABL/AB over catheter exchange, as the infection-free survival and the rate of recurrence are comparable.

Original languageEnglish (US)
Pages (from-to)457-464
Number of pages8
JournalPediatric Nephrology
Volume23
Issue number3
DOIs
StatePublished - Mar 1 2008

Fingerprint

Tissue Plasminogen Activator
Bacteremia
Catheters
Anti-Bacterial Agents
Therapeutics
Recurrence
Infection
Candida
Blood Vessels
Renal Dialysis
Retrospective Studies

Keywords

  • Antibiotic locks
  • Biofilms
  • Catheter survival
  • Catheter-related bacteremia
  • Tunneled-cuffed hemodialysis catheters

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Nephrology

Cite this

Onder, A. M., Chandar, J., Simon, N., Saint-Vil, M., Francoeur, D., Nwobi, O. I., ... Zilleruelo, G. (2008). Treatment of catheter-related bacteremia with tissue plasminogen activator antibiotic locks. Pediatric Nephrology, 23(3), 457-464. https://doi.org/10.1007/s00467-007-0687-8

Treatment of catheter-related bacteremia with tissue plasminogen activator antibiotic locks. / Onder, Ali Mirza; Chandar, Jayanthi; Simon, Nancy; Saint-Vil, Marie; Francoeur, Denise; Nwobi, Obioma Ikechukwu; Abitbol, Carolyn; Zilleruelo, Gaston.

In: Pediatric Nephrology, Vol. 23, No. 3, 01.03.2008, p. 457-464.

Research output: Contribution to journalArticle

Onder, AM, Chandar, J, Simon, N, Saint-Vil, M, Francoeur, D, Nwobi, OI, Abitbol, C & Zilleruelo, G 2008, 'Treatment of catheter-related bacteremia with tissue plasminogen activator antibiotic locks', Pediatric Nephrology, vol. 23, no. 3, pp. 457-464. https://doi.org/10.1007/s00467-007-0687-8
Onder AM, Chandar J, Simon N, Saint-Vil M, Francoeur D, Nwobi OI et al. Treatment of catheter-related bacteremia with tissue plasminogen activator antibiotic locks. Pediatric Nephrology. 2008 Mar 1;23(3):457-464. https://doi.org/10.1007/s00467-007-0687-8
Onder, Ali Mirza ; Chandar, Jayanthi ; Simon, Nancy ; Saint-Vil, Marie ; Francoeur, Denise ; Nwobi, Obioma Ikechukwu ; Abitbol, Carolyn ; Zilleruelo, Gaston. / Treatment of catheter-related bacteremia with tissue plasminogen activator antibiotic locks. In: Pediatric Nephrology. 2008 ; Vol. 23, No. 3. pp. 457-464.
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abstract = "This retrospective study was completed to investigate the effectiveness of tissue plasminogen activator (TPA) antibiotic locks (ABL) along with systemic antibiotics (AB) to clear catheter-related bacteremia (CRB) in children on chronic hemodialysis. There were 76 CRBs in 37 children. CRBs were successfully cleared with AB/ABL in 63/76 (83{\%}) cases. Ten of 76 (13{\%}) CRBs were symptomatic at 48 h of treatment. These were seven polymicrobial, two gram-negative, and one Candida CRB. 13/76 (17{\%}) episodes required catheter exchange, and all were wire-guided exchanges. TPA-ABL/AB cleared gram-positive and gram-negative CRBs significantly better than polymicrobial CRBs (p<0.01). The infection-free survival and the rate of recurrence at 45 days was not statistically different between the TPA-ABL/AB group and the catheter-exchange group. If CRB was symptomatic at 48 h of treatment, recurrence at 6 weeks was more frequent with persistent use of TPA-ABL/AB (p<0.05). There were no episodes of metastatic infections, catheter malfunction from occlusion, or catheter breakdown during the course of TPA-ABL treatments. In conclusion, TPA-ABL can be safely and effectively used in the management of CRB, increasing the probability of catheter survival and preserving the vascular access site. With the exception of polymicrobial CRB, there is no disadvantage in using TPA-ABL/AB over catheter exchange, as the infection-free survival and the rate of recurrence are comparable.",
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AU - Zilleruelo, Gaston

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N2 - This retrospective study was completed to investigate the effectiveness of tissue plasminogen activator (TPA) antibiotic locks (ABL) along with systemic antibiotics (AB) to clear catheter-related bacteremia (CRB) in children on chronic hemodialysis. There were 76 CRBs in 37 children. CRBs were successfully cleared with AB/ABL in 63/76 (83%) cases. Ten of 76 (13%) CRBs were symptomatic at 48 h of treatment. These were seven polymicrobial, two gram-negative, and one Candida CRB. 13/76 (17%) episodes required catheter exchange, and all were wire-guided exchanges. TPA-ABL/AB cleared gram-positive and gram-negative CRBs significantly better than polymicrobial CRBs (p<0.01). The infection-free survival and the rate of recurrence at 45 days was not statistically different between the TPA-ABL/AB group and the catheter-exchange group. If CRB was symptomatic at 48 h of treatment, recurrence at 6 weeks was more frequent with persistent use of TPA-ABL/AB (p<0.05). There were no episodes of metastatic infections, catheter malfunction from occlusion, or catheter breakdown during the course of TPA-ABL treatments. In conclusion, TPA-ABL can be safely and effectively used in the management of CRB, increasing the probability of catheter survival and preserving the vascular access site. With the exception of polymicrobial CRB, there is no disadvantage in using TPA-ABL/AB over catheter exchange, as the infection-free survival and the rate of recurrence are comparable.

AB - This retrospective study was completed to investigate the effectiveness of tissue plasminogen activator (TPA) antibiotic locks (ABL) along with systemic antibiotics (AB) to clear catheter-related bacteremia (CRB) in children on chronic hemodialysis. There were 76 CRBs in 37 children. CRBs were successfully cleared with AB/ABL in 63/76 (83%) cases. Ten of 76 (13%) CRBs were symptomatic at 48 h of treatment. These were seven polymicrobial, two gram-negative, and one Candida CRB. 13/76 (17%) episodes required catheter exchange, and all were wire-guided exchanges. TPA-ABL/AB cleared gram-positive and gram-negative CRBs significantly better than polymicrobial CRBs (p<0.01). The infection-free survival and the rate of recurrence at 45 days was not statistically different between the TPA-ABL/AB group and the catheter-exchange group. If CRB was symptomatic at 48 h of treatment, recurrence at 6 weeks was more frequent with persistent use of TPA-ABL/AB (p<0.05). There were no episodes of metastatic infections, catheter malfunction from occlusion, or catheter breakdown during the course of TPA-ABL treatments. In conclusion, TPA-ABL can be safely and effectively used in the management of CRB, increasing the probability of catheter survival and preserving the vascular access site. With the exception of polymicrobial CRB, there is no disadvantage in using TPA-ABL/AB over catheter exchange, as the infection-free survival and the rate of recurrence are comparable.

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