Treatment of central venous catheter fungal infection using liposomal amphotericin-B lock therapy

Bradley S. Buckler, Ralph N. Sams, Vita Lan-Ing Goei, Karthik R. Krishnan, Marci J. Bemis, Deidrea P. Parker, Dennis L. Murray

Research output: Contribution to journalArticle

37 Scopus citations


The current standard of care for a fungal central venous catheter infection in a pediatric patient usually requires removal without any other feasible options. Although removal may reduce the rate of Candida-associated complications, literature reviews question whether the outcomes of removal substantiate this being the standard of care. We report 6 cases of central venous catheter fungal infections treated with liposomal amphotericin-B lock therapy. These cases consisted of 4 patients, 2 of whom received recurrent therapy. In 4 of these cases, there was successful eradication of the infectious fungal agent, allowing continued use of the catheter. A controlled study of antifungal lock therapy should be considered as a potential alternative to removal.

Original languageEnglish (US)
Pages (from-to)762-764
Number of pages3
JournalPediatric Infectious Disease Journal
Issue number8
StatePublished - Jan 1 2008



  • Antifungal lock therapy
  • Central venous catheters
  • Fungal infections
  • Liposomal amphotericin-B

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Microbiology (medical)
  • Infectious Diseases

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