Treatment of central venous catheter fungal infection using liposomal amphotericin-B lock therapy

Bradley S. Buckler, Ralph N. Sams, Vita Lan-Ing Goei, Karthik R. Krishnan, Marci J. Bemis, Deidrea P. Parker, Dennis L. Murray

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

The current standard of care for a fungal central venous catheter infection in a pediatric patient usually requires removal without any other feasible options. Although removal may reduce the rate of Candida-associated complications, literature reviews question whether the outcomes of removal substantiate this being the standard of care. We report 6 cases of central venous catheter fungal infections treated with liposomal amphotericin-B lock therapy. These cases consisted of 4 patients, 2 of whom received recurrent therapy. In 4 of these cases, there was successful eradication of the infectious fungal agent, allowing continued use of the catheter. A controlled study of antifungal lock therapy should be considered as a potential alternative to removal.

Original languageEnglish (US)
Pages (from-to)762-764
Number of pages3
JournalPediatric Infectious Disease Journal
Volume27
Issue number8
DOIs
StatePublished - Jan 1 2008

Fingerprint

Central Venous Catheters
Mycoses
Standard of Care
Candida
Therapeutics
Catheters
Pediatrics
Infection
liposomal amphotericin B

Keywords

  • Antifungal lock therapy
  • Central venous catheters
  • Fungal infections
  • Liposomal amphotericin-B

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Microbiology (medical)
  • Infectious Diseases

Cite this

Treatment of central venous catheter fungal infection using liposomal amphotericin-B lock therapy. / Buckler, Bradley S.; Sams, Ralph N.; Goei, Vita Lan-Ing; Krishnan, Karthik R.; Bemis, Marci J.; Parker, Deidrea P.; Murray, Dennis L.

In: Pediatric Infectious Disease Journal, Vol. 27, No. 8, 01.01.2008, p. 762-764.

Research output: Contribution to journalArticle

Buckler, Bradley S. ; Sams, Ralph N. ; Goei, Vita Lan-Ing ; Krishnan, Karthik R. ; Bemis, Marci J. ; Parker, Deidrea P. ; Murray, Dennis L. / Treatment of central venous catheter fungal infection using liposomal amphotericin-B lock therapy. In: Pediatric Infectious Disease Journal. 2008 ; Vol. 27, No. 8. pp. 762-764.
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