Treatment of chronic experimental Staphylococcus aureus osteomyelitis with LY146032 and vancomycin

Q. N. Luu, T. B. Buxton, D. R. Nelson, John Peter Rissing

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LY146032 and vancomycin were compared as therapeutic agents in the treatment of chronic Staphylococcus aureus osteomyelitis in the rat. Quantitative cultures disclosed that one of 16, none of 16, and two of 17 tibiae were sterile from the control, LY146032, and vancomycin groups, respectively. From positive cultures, geometric mean staphylococcal CFU per gram of bone were as follows: control, 5.13±1.58; LY146032, 5.36±0.43 (p=0.57); and vancomycin, 4.33±1.73 (p=0.078). Mean gross pathology was decreased significantly in both treatment groups. LY146032 was no more effective than vancomycin in reducing bacterial counts.

Original languageEnglish (US)
Pages (from-to)562-563
Number of pages2
JournalEuropean Journal of Clinical Microbiology & Infectious Diseases
Issue number6
Publication statusPublished - Jun 1 1989


ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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