Treatment of hemorrhagic shock with a new vasodilator

J. A. Vick, C. R. Roberts, M. H. Heiffer, Robert William Caldwell, A. Nies

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

54 dogs and 14 rhesus monkeys were anesthetized with sodium pentobarbital (30 mg/kg, iv). 13 unanesthetized cross bred sheep were also used. Changes in arterial and central venous blood pressures, EKG, and heart rate were continuously recorded, and determinations of pH, pO 2 and pCO 2 were made hourly. Cortical EEG was also monitored in the sheep as an indicator of brain oxygenation. All animals were bled to a mean arterial pressure of from 45 to 50 mm Hg and maintained at that level for 8 hr. 3 hr after hemorrhage, animals were paired at random into either a control or a treated group. Control animals received no therapy, while the treated groups were given WR 2823, 50 mg/kg, iv. Prior to treatment, all animals showed progressive deterioration of the cardiovascular system, generalized acidosis, and pooling of blood. Controls continued to deteriorate and exhibited an early bradycardia, peripheral acidosis, and generalized pooling of the peripheral circulation. They expired from 8 to 24 hr. In contrast, treated animals showed slow yet sustained recovery of most parameters to prehemorrhage levels. At 8 hr, arterial blood pH was stable and venous pO 2 and arterial pCO 2 approached normal values. A significant improvement in survival populations was noted in all groups of treated animals.

Original languageEnglish (US)
Pages (from-to)490-494
Number of pages5
JournalMilitary Medicine
Volume138
Issue number8
StatePublished - Dec 1 1973
Externally publishedYes

Fingerprint

Hemorrhagic Shock
Vasodilator Agents
Acidosis
Sheep
Central Venous Pressure
Venous Pressure
Pentobarbital
Bradycardia
Cardiovascular System
Macaca mulatta
Electroencephalography
Arterial Pressure
Electrocardiography
Reference Values
Heart Rate
Dogs
Hemorrhage
Brain
Population

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Cite this

Vick, J. A., Roberts, C. R., Heiffer, M. H., Caldwell, R. W., & Nies, A. (1973). Treatment of hemorrhagic shock with a new vasodilator. Military Medicine, 138(8), 490-494.

Treatment of hemorrhagic shock with a new vasodilator. / Vick, J. A.; Roberts, C. R.; Heiffer, M. H.; Caldwell, Robert William; Nies, A.

In: Military Medicine, Vol. 138, No. 8, 01.12.1973, p. 490-494.

Research output: Contribution to journalArticle

Vick, JA, Roberts, CR, Heiffer, MH, Caldwell, RW & Nies, A 1973, 'Treatment of hemorrhagic shock with a new vasodilator', Military Medicine, vol. 138, no. 8, pp. 490-494.
Vick JA, Roberts CR, Heiffer MH, Caldwell RW, Nies A. Treatment of hemorrhagic shock with a new vasodilator. Military Medicine. 1973 Dec 1;138(8):490-494.
Vick, J. A. ; Roberts, C. R. ; Heiffer, M. H. ; Caldwell, Robert William ; Nies, A. / Treatment of hemorrhagic shock with a new vasodilator. In: Military Medicine. 1973 ; Vol. 138, No. 8. pp. 490-494.
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