Treatment of Postoperative Ileus After Bowel Surgery with Low-Dose Intravenous Erythromycin

Andrew J. Lightfoot, Mary Eno, Karl J. Kreder, Michael A. O'Donnell, Satish Sanku Chander Rao, Richard D. Williams

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Objectives: Treatment of postoperative ileus remains unsatisfactory. Erythromycin (EM), a macrolide antibiotic, has prokinetic effects on the gut. We investigated whether intravenous erythromycin decreases the time to the return of normal bowel function after bowel surgery in patients with bladder cancer and interstitial cystitis who have undergone cystectomy and urinary diversion. Methods: We conducted a double-blind, randomized, placebo-controlled study of 22 volunteers. On the first postoperative day, patients began receiving intravenous erythromycin (125 mg) or placebo every 8 hours (maximum of 21 doses). The patients' ability to tolerate a general diet and return of bowel function was monitored. Results: A general diet was tolerated at a median of 9 days postoperatively for the EM arm and 8 for the placebo arm (P = 0.60). The first bowel sounds were detected at an average of 2 postoperative days for the EM arm and 3 for the placebo arm (P = 0.88). First flatus was present an average of 5 days postoperatively for both study arms (P = 0.35). The first bowel movement was present an average of 6 days postoperatively for the EM arm and 5 for the placebo arm (P = 0.98). Conclusions: No significant difference was found between EM and placebo with regard to the onset of bowel sounds, passage of flatus, passage of the first bowel movement, and the time to tolerate a general diet. These data indicate that erythromycin is not useful in improving postoperative bowel function.

Original languageEnglish (US)
Pages (from-to)611-615
Number of pages5
JournalUrology
Volume69
Issue number4
DOIs
StatePublished - Apr 1 2007

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Ileus
Erythromycin
Placebos
Flatulence
Therapeutics
Diet
Interstitial Cystitis
Urinary Diversion
Cystectomy
Macrolides
Urinary Bladder Neoplasms
Volunteers
Anti-Bacterial Agents

ASJC Scopus subject areas

  • Urology

Cite this

Lightfoot, A. J., Eno, M., Kreder, K. J., O'Donnell, M. A., Rao, S. S. C., & Williams, R. D. (2007). Treatment of Postoperative Ileus After Bowel Surgery with Low-Dose Intravenous Erythromycin. Urology, 69(4), 611-615. https://doi.org/10.1016/j.urology.2006.12.027

Treatment of Postoperative Ileus After Bowel Surgery with Low-Dose Intravenous Erythromycin. / Lightfoot, Andrew J.; Eno, Mary; Kreder, Karl J.; O'Donnell, Michael A.; Rao, Satish Sanku Chander; Williams, Richard D.

In: Urology, Vol. 69, No. 4, 01.04.2007, p. 611-615.

Research output: Contribution to journalArticle

Lightfoot, AJ, Eno, M, Kreder, KJ, O'Donnell, MA, Rao, SSC & Williams, RD 2007, 'Treatment of Postoperative Ileus After Bowel Surgery with Low-Dose Intravenous Erythromycin', Urology, vol. 69, no. 4, pp. 611-615. https://doi.org/10.1016/j.urology.2006.12.027
Lightfoot, Andrew J. ; Eno, Mary ; Kreder, Karl J. ; O'Donnell, Michael A. ; Rao, Satish Sanku Chander ; Williams, Richard D. / Treatment of Postoperative Ileus After Bowel Surgery with Low-Dose Intravenous Erythromycin. In: Urology. 2007 ; Vol. 69, No. 4. pp. 611-615.
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