Treatment of severe hemolytic anemia caused by clostridium perfringens sepsis in a liver transplant recipient

John Watt, Albert Amini, Jarrod Mosier, Monica Gustafson, Julie L. Wynne, Randall Friese, Rainer W G Gruessner, Peter Rhee, Terence OKeeffe

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: Clostridium perfringens bacteremia accompanied by extensive intravascular hemolysis is an almost inescapably fatal infection. Methods: Case report and literature review. Results: A 52-year-old man with a recent history of liver transplantation developed sepsis and severe hemolytic anemia. The patient had multiple organ dysfunction syndrome and required aggressive transfusion, antibiotics, and continuous hemodialysis. Blood cultures grew C. perfringens. With appropriate resuscitation and antibiotic treatment, the patient had a complete, although complicated recovery. Conclusion: This is the first reported case of a liver transplant patient developing fulminant C. perfringens sepsis with hemolysis. This infection usually kills patients within hours of presentation. Early recognition and aggressive treatment is necessary to avoid this outcome.

Original languageEnglish (US)
Pages (from-to)60-62
Number of pages3
JournalSurgical Infections
Volume13
Issue number1
DOIs
StatePublished - Feb 1 2012
Externally publishedYes

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Clostridium perfringens
Hemolytic Anemia
Sepsis
Liver
Hemolysis
Anti-Bacterial Agents
Multiple Organ Failure
Therapeutics
Bacteremia
Infection
Resuscitation
Liver Transplantation
Renal Dialysis
Transplants
Transplant Recipients

ASJC Scopus subject areas

  • Surgery
  • Infectious Diseases
  • Microbiology (medical)

Cite this

Treatment of severe hemolytic anemia caused by clostridium perfringens sepsis in a liver transplant recipient. / Watt, John; Amini, Albert; Mosier, Jarrod; Gustafson, Monica; Wynne, Julie L.; Friese, Randall; Gruessner, Rainer W G; Rhee, Peter; OKeeffe, Terence.

In: Surgical Infections, Vol. 13, No. 1, 01.02.2012, p. 60-62.

Research output: Contribution to journalArticle

Watt, J, Amini, A, Mosier, J, Gustafson, M, Wynne, JL, Friese, R, Gruessner, RWG, Rhee, P & OKeeffe, T 2012, 'Treatment of severe hemolytic anemia caused by clostridium perfringens sepsis in a liver transplant recipient', Surgical Infections, vol. 13, no. 1, pp. 60-62. https://doi.org/10.1089/sur.2010.092
Watt, John ; Amini, Albert ; Mosier, Jarrod ; Gustafson, Monica ; Wynne, Julie L. ; Friese, Randall ; Gruessner, Rainer W G ; Rhee, Peter ; OKeeffe, Terence. / Treatment of severe hemolytic anemia caused by clostridium perfringens sepsis in a liver transplant recipient. In: Surgical Infections. 2012 ; Vol. 13, No. 1. pp. 60-62.
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