Treatment-refractory schizophrenia

Peter F Buckley, Nitin Sudhakar Shendarkar

Research output: Contribution to journalReview article

19 Citations (Scopus)

Abstract

Purpose of review: The aim of this article is to critically review the current literature on treatment-refractory schizophrenia with an emphasis on emergent themes and key findings. Recent findings: New information continues to emerge on the impact of each second-generation antipsychotic on the treatment-refractory patient population and on the traditionally more difficult-to-treat components (e.g. cognition, suicidality, violence) of the illness. There are continued efforts with pharmacogenetics to predict response and side-effect risk with antipsychotic medications. Polypharmacy continues to be a major and poorly understood treatment practice. Summary: Our field is advancing the therapeutic nuances of therapy with second-generation antipsychotics in treatment-refractory schizophrenia. Additionally, there is a growing appreciation of the emergent adverse-effect profile of antipsychotic medications and these risk-benefit considerations are more pronounced in severely ill patients.

Original languageEnglish (US)
Pages (from-to)165-173
Number of pages9
JournalCurrent Opinion in Psychiatry
Volume18
Issue number2
DOIs
StatePublished - Jan 1 2005

Fingerprint

Schizophrenia
Antipsychotic Agents
Therapeutics
Polypharmacy
Pharmacogenetics
Violence
Cognition
Population

Keywords

  • Augmentation
  • Cognition
  • Polypharmacy
  • Treatment-refractory schizophrenia

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Treatment-refractory schizophrenia. / Buckley, Peter F; Shendarkar, Nitin Sudhakar.

In: Current Opinion in Psychiatry, Vol. 18, No. 2, 01.01.2005, p. 165-173.

Research output: Contribution to journalReview article

Buckley, Peter F ; Shendarkar, Nitin Sudhakar. / Treatment-refractory schizophrenia. In: Current Opinion in Psychiatry. 2005 ; Vol. 18, No. 2. pp. 165-173.
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