Tregs strip dendritic cells of CD70 to regulate Th1 differentiation

Lukasz Wojciech, Leszek Ignatowicz

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

When the immune system encounters an antigen, the response can result in the mobilization of effector cells or in tolerance. The outcome is largely dependent on immunosuppressive CD4 T cells that express the transcription factor Foxp3 (Tregs). Yet, how Tregs control different immune effector cells remains elusive. In this issue of The EMBO Journal, Dhainaut et al report on a novel mechanism used by Tregs to prevent differentiation of naïve CD4 T cells to proinflammatory Th1CD4 (Th1) effectors. A recent study reveals a new mechanism by which regulatory T cells suppress excessive inflammatory responses.

Original languageEnglish (US)
Pages (from-to)1290-1292
Number of pages3
JournalEMBO Journal
Volume34
Issue number10
DOIs
StatePublished - May 12 2015

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T-cells
Dendritic Cells
T-Lymphocytes
Regulatory T-Lymphocytes
Immunosuppressive Agents
Immune System
Transcription Factors
Immune system
Antigens

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

Cite this

Tregs strip dendritic cells of CD70 to regulate Th1 differentiation. / Wojciech, Lukasz; Ignatowicz, Leszek.

In: EMBO Journal, Vol. 34, No. 10, 12.05.2015, p. 1290-1292.

Research output: Contribution to journalArticle

Wojciech, Lukasz ; Ignatowicz, Leszek. / Tregs strip dendritic cells of CD70 to regulate Th1 differentiation. In: EMBO Journal. 2015 ; Vol. 34, No. 10. pp. 1290-1292.
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