TY - JOUR
T1 - Trichosporon infection
AU - Vazquez, Jose A.
N1 - Funding Information:
Disclosure Dr. Vazquez has received grants from and been a speaker for Pfizer; has been a speaker and consultant for Astellas; and has received grants from Merck.
PY - 2010/3
Y1 - 2010/3
N2 - Yeast exist throughout nature in association with soil, plants, mammals, and fish. As a result of this continued exposure, all humans are exposed to many different types of yeast through a variety of different routes. Recently, because of the increased population of immunocompromised patients and the extensive use of different antifungals, the incidence of infections due to non-Candida yeast has increased. Of these classic "nonpathogenic" yeast, Trichosporon species have been increasingly described producing deep-seated and disseminated infections that are difficult to predict and diagnose. In addition, the different species of Trichosporon have been found to be less susceptible or resistant to commonly used antifungals. Because of this intrinsic variation in antifungal susceptibility and the fact that these infections are generally seen in severely immunocompromised hosts, they are associated with significant morbidity and mortality, despite their known "nonpathogenic" characteristics described in superficial infections.
AB - Yeast exist throughout nature in association with soil, plants, mammals, and fish. As a result of this continued exposure, all humans are exposed to many different types of yeast through a variety of different routes. Recently, because of the increased population of immunocompromised patients and the extensive use of different antifungals, the incidence of infections due to non-Candida yeast has increased. Of these classic "nonpathogenic" yeast, Trichosporon species have been increasingly described producing deep-seated and disseminated infections that are difficult to predict and diagnose. In addition, the different species of Trichosporon have been found to be less susceptible or resistant to commonly used antifungals. Because of this intrinsic variation in antifungal susceptibility and the fact that these infections are generally seen in severely immunocompromised hosts, they are associated with significant morbidity and mortality, despite their known "nonpathogenic" characteristics described in superficial infections.
KW - Antifungal
KW - Disseminated trichosporonosis
KW - Immunocompromised
KW - Trichosporon infections
KW - Yeast
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U2 - 10.1007/s12281-010-0005-y
DO - 10.1007/s12281-010-0005-y
M3 - Review article
AN - SCOPUS:79952193879
SN - 1936-3761
VL - 4
SP - 52
EP - 58
JO - Current Fungal Infection Reports
JF - Current Fungal Infection Reports
IS - 1
ER -