Tryptophan catabolism and T cell responses

Andrew L. Mellor, David Munn, Phillip Chandler, Denn Keskin, Theodore Johnson, Brendan Marshall, Kanchan Jhaver, Babak Baban

Research output: Contribution to journalArticle

70 Citations (Scopus)

Abstract

Cells expressing indoleamine 2,3 dioxygenase (IDO) play key roles in regulating adaptive immune responses orchestrated by T cells. In this report we discuss our working model, the tryptophan depletion hypothesis, to explain links between IDO expression and inhibition of T cell responses. We posit that IDO+ cells, particularly professional antigen presenting cells (APCs) promote T cell entry but block cell cycle progression due to tryptophan catabolism. We discuss experimental evidence supporting predictions from the tryptophan depletion hypothesis and the implications that this model has for understanding the origin of tolerant states that explain immunological paradoxes, such as fetal survival, tumor persistence and failure to eradicate pathogens like HIV that cause persistent infections.

Original languageEnglish (US)
Pages (from-to)27-35
Number of pages9
JournalAdvances in Experimental Medicine and Biology
Volume527
StatePublished - Dec 1 2003

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Indoleamine-Pyrrole 2,3,-Dioxygenase
T-cells
Tryptophan
T-Lymphocytes
Cells
Adaptive Immunity
Pathogens
Antigen-Presenting Cells
Tumors
Cell Cycle
HIV
Infection
Neoplasms

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Tryptophan catabolism and T cell responses. / Mellor, Andrew L.; Munn, David; Chandler, Phillip; Keskin, Denn; Johnson, Theodore; Marshall, Brendan; Jhaver, Kanchan; Baban, Babak.

In: Advances in Experimental Medicine and Biology, Vol. 527, 01.12.2003, p. 27-35.

Research output: Contribution to journalArticle

Mellor, AL, Munn, D, Chandler, P, Keskin, D, Johnson, T, Marshall, B, Jhaver, K & Baban, B 2003, 'Tryptophan catabolism and T cell responses', Advances in Experimental Medicine and Biology, vol. 527, pp. 27-35.
Mellor AL, Munn D, Chandler P, Keskin D, Johnson T, Marshall B et al. Tryptophan catabolism and T cell responses. Advances in Experimental Medicine and Biology. 2003 Dec 1;527:27-35.
Mellor, Andrew L. ; Munn, David ; Chandler, Phillip ; Keskin, Denn ; Johnson, Theodore ; Marshall, Brendan ; Jhaver, Kanchan ; Baban, Babak. / Tryptophan catabolism and T cell responses. In: Advances in Experimental Medicine and Biology. 2003 ; Vol. 527. pp. 27-35.
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