Tryptophan catabolism prevents maternal T cells from activating lethal anti-fetal immune responses

Andrew L. Mellor, David H. Munn

Research output: Contribution to journalArticle

86 Scopus citations

Abstract

The murine conceptus is protected from maternal immunity by cells expressing indoleamine dioxygenase (IDO), which catabolizes tryptophan. Induction of lethal maternal anti-fetal immunity requires effective pharmacologic inhibition of IDO enzyme activity and the presence of maternal T cells, but not B cells and also depends on the degree of maternal-fetal tissue incompatibility. Based on these findings, we propose a model to explain the role of IDO in suppressing maternal immunity and the mechanism of fetal allograft rejection, when IDO activity is inhibited during gestation. This model incorporates observations that fetal allograft rejection is T cell dependent, antibody-independent and is accompanied by a novel type of inflammation involving extensive complement deposition at the maternal-fetal interface, when IDO activity is blocked during murine pregnancy.

Original languageEnglish (US)
Pages (from-to)5-13
Number of pages9
JournalJournal of Reproductive Immunology
Volume52
Issue number1-2
DOIs
StatePublished - Oct 11 2001

Keywords

  • Fetal allograft
  • Indoleamine 2,3-dioxygenase
  • Maternal immunity
  • Pregnancy

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Reproductive Medicine
  • Obstetrics and Gynecology

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