Tryptophan catabolism, T cell responses & tissue transplantation: Innovative approaches to regulating immune responses

Andrew L. Mellor, David H. Munn, Phillip Chandler, Derin Keskin, Theodore Johnson, Brendan Marshall Babak Baban, Jeffrey Lee

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The method for tyrptophan catabolism, T cells and tissue transplantation which are useful in regulating and promoting adaptive immune responses in mammals are discussed. A hypothesis that cells expressing IDO inhibited T cells activation in response to the antigenic challenge due to local catabolism of the essential amino acid tryptophan was proposed. A model showing that T cells are sensitive to the amount of free tryptophan available during a critical period following antigen simulation was also proposed. It was shown that the cells transfected to express IDO inhibit T cell responses in vitro and in vivo.

Original languageEnglish (US)
Title of host publicationThird Smith and Nephew International Symposium - Translating Tissue Engineering into Products
StatePublished - Dec 1 2002
EventThird Smith and Nephew International Symposium - Translating Tissue Engineering into Products - Atlanta, GA, United States
Duration: Oct 13 2002Oct 16 2002

Other

OtherThird Smith and Nephew International Symposium - Translating Tissue Engineering into Products
CountryUnited States
CityAtlanta, GA
Period10/13/0210/16/02

ASJC Scopus subject areas

  • Engineering(all)

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    Mellor, A. L., Munn, D. H., Chandler, P., Keskin, D., Johnson, T., Baban, B. M. B., & Lee, J. (2002). Tryptophan catabolism, T cell responses & tissue transplantation: Innovative approaches to regulating immune responses. In Third Smith and Nephew International Symposium - Translating Tissue Engineering into Products