Tumor angiogenesis as a prognostic indicator in T2-T4 oral cavity squamous cell carcinoma

A clinical-pathologic correlation

Lyon L. Gleich, Paul Williams Biddinger, Frank D. Duperier, Jack L. Gluckman

Research output: Contribution to journalArticle

84 Citations (Scopus)

Abstract

Background. Tumor angiogenesis has been shown to correlate with tumor size, metastatic potential, and prognosis in breast and other cancers. Studies in head and neck cancer have suggested a similar correlation, but results have been inconclusive. This study was performed to determine the correlation between angiogenesis and oral tumor behavior. Methods. Tumor angiogenesis was evaluated in 31 T2-T4 primary oral cavity squamous cell carcinomas by quantitating the microvessel density with two different anti- endothelial cell antigens, factor VIII antigen (FVIIIAg) and CD-31. The stains were compared to assess whether these antigens yielded complimentary results. The microvessel densities were correlated with T stage and N stage and patient survival. Results. FVIIIAg and CD-31 staining yielded consistent microvessel densities, but FVIIIAg was generally more uniform and easier to interpret, increasing microvessel density was seen with increasing T stage and N stage; however, there was considerable overlap and no correlation with survival. Conclusions. These results suggest that oral tumors are less angiogenesis dependent than tumors in other sites. Tumor angiogenesis, as currently measured, is not of value in predicting tumor aggressiveness in patients with oral cavity carcinoma.

Original languageEnglish (US)
Pages (from-to)276-280
Number of pages5
JournalHead and Neck
Volume19
Issue number4
StatePublished - Jul 1 1997
Externally publishedYes

Fingerprint

Mouth
Squamous Cell Carcinoma
Microvessels
Neoplasms
Factor VIII
CD Antigens
Antigens
Survival
Head and Neck Neoplasms
Coloring Agents
Endothelial Cells
Staining and Labeling
Breast Neoplasms
Carcinoma

Keywords

  • Angiogenesis
  • Metastases outcomes
  • Oral cavity
  • Squamous cell carcinoma

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Tumor angiogenesis as a prognostic indicator in T2-T4 oral cavity squamous cell carcinoma : A clinical-pathologic correlation. / Gleich, Lyon L.; Biddinger, Paul Williams; Duperier, Frank D.; Gluckman, Jack L.

In: Head and Neck, Vol. 19, No. 4, 01.07.1997, p. 276-280.

Research output: Contribution to journalArticle

@article{3ead57aed3f34ba084691ba3bcf579c0,
title = "Tumor angiogenesis as a prognostic indicator in T2-T4 oral cavity squamous cell carcinoma: A clinical-pathologic correlation",
abstract = "Background. Tumor angiogenesis has been shown to correlate with tumor size, metastatic potential, and prognosis in breast and other cancers. Studies in head and neck cancer have suggested a similar correlation, but results have been inconclusive. This study was performed to determine the correlation between angiogenesis and oral tumor behavior. Methods. Tumor angiogenesis was evaluated in 31 T2-T4 primary oral cavity squamous cell carcinomas by quantitating the microvessel density with two different anti- endothelial cell antigens, factor VIII antigen (FVIIIAg) and CD-31. The stains were compared to assess whether these antigens yielded complimentary results. The microvessel densities were correlated with T stage and N stage and patient survival. Results. FVIIIAg and CD-31 staining yielded consistent microvessel densities, but FVIIIAg was generally more uniform and easier to interpret, increasing microvessel density was seen with increasing T stage and N stage; however, there was considerable overlap and no correlation with survival. Conclusions. These results suggest that oral tumors are less angiogenesis dependent than tumors in other sites. Tumor angiogenesis, as currently measured, is not of value in predicting tumor aggressiveness in patients with oral cavity carcinoma.",
keywords = "Angiogenesis, Metastases outcomes, Oral cavity, Squamous cell carcinoma",
author = "Gleich, {Lyon L.} and Biddinger, {Paul Williams} and Duperier, {Frank D.} and Gluckman, {Jack L.}",
year = "1997",
month = "7",
day = "1",
language = "English (US)",
volume = "19",
pages = "276--280",
journal = "Head and Neck Surgery",
issn = "0148-6403",
publisher = "Wiley-Liss Inc.",
number = "4",

}

TY - JOUR

T1 - Tumor angiogenesis as a prognostic indicator in T2-T4 oral cavity squamous cell carcinoma

T2 - A clinical-pathologic correlation

AU - Gleich, Lyon L.

AU - Biddinger, Paul Williams

AU - Duperier, Frank D.

AU - Gluckman, Jack L.

PY - 1997/7/1

Y1 - 1997/7/1

N2 - Background. Tumor angiogenesis has been shown to correlate with tumor size, metastatic potential, and prognosis in breast and other cancers. Studies in head and neck cancer have suggested a similar correlation, but results have been inconclusive. This study was performed to determine the correlation between angiogenesis and oral tumor behavior. Methods. Tumor angiogenesis was evaluated in 31 T2-T4 primary oral cavity squamous cell carcinomas by quantitating the microvessel density with two different anti- endothelial cell antigens, factor VIII antigen (FVIIIAg) and CD-31. The stains were compared to assess whether these antigens yielded complimentary results. The microvessel densities were correlated with T stage and N stage and patient survival. Results. FVIIIAg and CD-31 staining yielded consistent microvessel densities, but FVIIIAg was generally more uniform and easier to interpret, increasing microvessel density was seen with increasing T stage and N stage; however, there was considerable overlap and no correlation with survival. Conclusions. These results suggest that oral tumors are less angiogenesis dependent than tumors in other sites. Tumor angiogenesis, as currently measured, is not of value in predicting tumor aggressiveness in patients with oral cavity carcinoma.

AB - Background. Tumor angiogenesis has been shown to correlate with tumor size, metastatic potential, and prognosis in breast and other cancers. Studies in head and neck cancer have suggested a similar correlation, but results have been inconclusive. This study was performed to determine the correlation between angiogenesis and oral tumor behavior. Methods. Tumor angiogenesis was evaluated in 31 T2-T4 primary oral cavity squamous cell carcinomas by quantitating the microvessel density with two different anti- endothelial cell antigens, factor VIII antigen (FVIIIAg) and CD-31. The stains were compared to assess whether these antigens yielded complimentary results. The microvessel densities were correlated with T stage and N stage and patient survival. Results. FVIIIAg and CD-31 staining yielded consistent microvessel densities, but FVIIIAg was generally more uniform and easier to interpret, increasing microvessel density was seen with increasing T stage and N stage; however, there was considerable overlap and no correlation with survival. Conclusions. These results suggest that oral tumors are less angiogenesis dependent than tumors in other sites. Tumor angiogenesis, as currently measured, is not of value in predicting tumor aggressiveness in patients with oral cavity carcinoma.

KW - Angiogenesis

KW - Metastases outcomes

KW - Oral cavity

KW - Squamous cell carcinoma

UR - http://www.scopus.com/inward/record.url?scp=0030991303&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030991303&partnerID=8YFLogxK

M3 - Article

VL - 19

SP - 276

EP - 280

JO - Head and Neck Surgery

JF - Head and Neck Surgery

SN - 0148-6403

IS - 4

ER -