Tumor necrosis factor-α in cisplatin nephrotoxicity: A homebred foe?

Z. Dong, S. S. Atherton

Research output: Contribution to journal › Comment/debate

40 Citations (Scopus)

Abstract

A robust inflammatory response involving tumor necrosis factor-α (TNFα) is induced during cisplatin nephrotoxicity. Using chimeric models, Reeves and colleagues now demonstrate that resident kidney cells, rather than infiltrating immune cells, are the major producers of TNF-α. Blockade of TNFα attenuates inflammation and associated kidney injury.

Original languageEnglish (US)
Pages (from-to)5-7
Number of pages3
JournalKidney International
Volume72
Issue number1
DOIs
StatePublished - Jul 2007

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Cisplatin
Tumor Necrosis Factor-alpha
Kidney
Inflammation
Wounds and Injuries

ASJC Scopus subject areas

  • Nephrology

Cite this

Tumor necrosis factor-α in cisplatin nephrotoxicity : A homebred foe? / Dong, Z.; Atherton, S. S.

In: Kidney International, Vol. 72, No. 1, 07.2007, p. 5-7.

Research output: Contribution to journal › Comment/debate

Dong, Z & Atherton, SS 2007, 'Tumor necrosis factor-α in cisplatin nephrotoxicity: A homebred foe?', Kidney International, vol. 72, no. 1, pp. 5-7. https://doi.org/10.1038/sj.ki.5002320
Dong Z, Atherton SS. Tumor necrosis factor-α in cisplatin nephrotoxicity: A homebred foe? Kidney International. 2007 Jul;72(1):5-7. https://doi.org/10.1038/sj.ki.5002320
Dong, Z. ; Atherton, S. S. / Tumor necrosis factor-α in cisplatin nephrotoxicity : A homebred foe?. In: Kidney International. 2007 ; Vol. 72, No. 1. pp. 5-7.
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