Tumor necrosis factor-α in cisplatin nephrotoxicity: A homebred foe?

Z. Dong; S. S. Atherton

doi:10.1038/sj.ki.5002320

Tumor necrosis factor-α in cisplatin nephrotoxicity: A homebred foe?

Z. Dong, S. S. Atherton

Cellular Biology and Anatomy

Research output: Contribution to journal › Comment/debate › peer-review

40 Scopus citations

Abstract

A robust inflammatory response involving tumor necrosis factor-α (TNFα) is induced during cisplatin nephrotoxicity. Using chimeric models, Reeves and colleagues now demonstrate that resident kidney cells, rather than infiltrating immune cells, are the major producers of TNF-α. Blockade of TNFα attenuates inflammation and associated kidney injury.

Original language	English (US)
Pages (from-to)	5-7
Number of pages	3
Journal	Kidney International
Volume	72
Issue number	1
DOIs	https://doi.org/10.1038/sj.ki.5002320
State	Published - Jul 2007

ASJC Scopus subject areas

Nephrology

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10.1038/sj.ki.5002320

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title = "Tumor necrosis factor-α in cisplatin nephrotoxicity: A homebred foe?",

abstract = "A robust inflammatory response involving tumor necrosis factor-α (TNFα) is induced during cisplatin nephrotoxicity. Using chimeric models, Reeves and colleagues now demonstrate that resident kidney cells, rather than infiltrating immune cells, are the major producers of TNF-α. Blockade of TNFα attenuates inflammation and associated kidney injury.",

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