Tumor necrosis factor-α in cisplatin nephrotoxicity: A homebred foe?

Z. Dong, S. S. Atherton

Research output: Contribution to journalComment/debate

40 Scopus citations


A robust inflammatory response involving tumor necrosis factor-α (TNFα) is induced during cisplatin nephrotoxicity. Using chimeric models, Reeves and colleagues now demonstrate that resident kidney cells, rather than infiltrating immune cells, are the major producers of TNF-α. Blockade of TNFα attenuates inflammation and associated kidney injury.

Original languageEnglish (US)
Pages (from-to)5-7
Number of pages3
JournalKidney International
Issue number1
StatePublished - Jul 2007


ASJC Scopus subject areas

  • Nephrology

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