Abstract
A robust inflammatory response involving tumor necrosis factor-α (TNFα) is induced during cisplatin nephrotoxicity. Using chimeric models, Reeves and colleagues now demonstrate that resident kidney cells, rather than infiltrating immune cells, are the major producers of TNF-α. Blockade of TNFα attenuates inflammation and associated kidney injury.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 5-7 |
| Number of pages | 3 |
| Journal | Kidney International |
| Volume | 72 |
| Issue number | 1 |
| DOIs |
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| State | Published - Jul 2007 |
ASJC Scopus subject areas
- Nephrology
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Cite this
Dong, Z., & Atherton, S. S. (2007). Tumor necrosis factor-α in cisplatin nephrotoxicity: A homebred foe? Kidney International, 72(1), 5-7. https://doi.org/10.1038/sj.ki.5002320