Tumor-to-tumor metastasis: Pathology and neuroimaging considerations

Patricia Moody, Kevin Murtagh, Sarat Piduru, Steven Brem, Reed Murtagh, Amyn M. Rojiani

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

The phenomenon of tumor-to-tumor metastasis has been reported in the literature for over a century. However, it remains fairly uncommon, with fewer than 100 cases being described during that time. Virtually any benign or malignant tumor can be a recipient, but meningiomas have been implicated as the most common intracranial neoplasm to harbor metastasis. The donor neoplasm is most frequently lung or breast carcinoma, while rare cases of metastasis from other primary tumors have been reported. We report here three examples of such rare metastases. This case series reports the first documented instance involving rectal adenocarcinoma. In addition, we report two cases of metastatic prostate adenocarcinoma to a meningioma; to date of which only three cases have been published. The terms "tumor-to-tumor metastasis" and "collision tumor" are addressed, as are details of the pathology. The limitations of standard radiological imaging techniques, such as standard CT and MR, which cannot reliably identify the presence of metastasis within a meningioma are compared with physiology-based neuroimaging methods, such as perfusion MR and MR spectroscopy, which may be more useful in noninvasively differentiating tumor histology.

Original languageEnglish (US)
Pages (from-to)367-373
Number of pages7
JournalInternational Journal of Clinical and Experimental Pathology
Volume5
Issue number4
StatePublished - Jul 31 2012

Fingerprint

Neuroimaging
Pathology
Neoplasm Metastasis
Neoplasms
Meningioma
Adenocarcinoma
Brain Neoplasms
Prostate
Histology
Magnetic Resonance Spectroscopy
Perfusion
Breast Neoplasms
Lung

Keywords

  • Adenocarcinoma
  • Meningioma
  • Neuroimaging
  • Pathology
  • Tumor-to-tumor metastasis

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

Cite this

Tumor-to-tumor metastasis : Pathology and neuroimaging considerations. / Moody, Patricia; Murtagh, Kevin; Piduru, Sarat; Brem, Steven; Murtagh, Reed; Rojiani, Amyn M.

In: International Journal of Clinical and Experimental Pathology, Vol. 5, No. 4, 31.07.2012, p. 367-373.

Research output: Contribution to journalArticle

Moody, Patricia ; Murtagh, Kevin ; Piduru, Sarat ; Brem, Steven ; Murtagh, Reed ; Rojiani, Amyn M. / Tumor-to-tumor metastasis : Pathology and neuroimaging considerations. In: International Journal of Clinical and Experimental Pathology. 2012 ; Vol. 5, No. 4. pp. 367-373.
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