Tumour necrosis factor production in Falciparum malaria and its association with schizont rupture

D. Kwiatkowski, J. G. Cannon, K. R. Manogue, A. Cerami, C. A. Dinarello, B. M. Greenwood

Research output: Contribution to journalArticle

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Abstract

To investigate the involvement of tumour necrosis factor (TNF) in human malaria, we studied TNF production in patients infected with Plasmodium falciparum, and in co-cultures of human mononuclear cells and malaria parasites in vitro. In the examined sample, plasma TNF levels of over 39 pg/ml were detected in the plasma of 59% of Gambian children with acute malaria, 17% of convalscents, 9% of children with mild infections other than malaria, and 7% of healthy Gambian adults. Mononuclear cells of acute malaria patients, when stimulated with endotoxin in vitro, secreted twice as much TNF as did those of convalescent individuals, and three times that of healthy adult controls. Erythrocytic cultures of P. falciparum stimulated increased TNF secretion by mononuclear cells from uninfected individuals, and a sharo rise in the rate of secretion occurred shortly after schizont rupture. We suggest that malaria fever is mediated, at least in part, through paroxysmal TNF release associated with schizont rupture.

Original languageEnglish (US)
Pages (from-to)361-366
Number of pages6
JournalClinical and Experimental Immunology
Volume77
Issue number3
StatePublished - Jan 1 1989

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Schizonts
Falciparum Malaria
Rupture
Tumor Necrosis Factor-alpha
Malaria
Plasmodium falciparum
Coculture Techniques
Endotoxins
Parasites
Fever
Infection

ASJC Scopus subject areas

  • Immunology

Cite this

Kwiatkowski, D., Cannon, J. G., Manogue, K. R., Cerami, A., Dinarello, C. A., & Greenwood, B. M. (1989). Tumour necrosis factor production in Falciparum malaria and its association with schizont rupture. Clinical and Experimental Immunology, 77(3), 361-366.

Tumour necrosis factor production in Falciparum malaria and its association with schizont rupture. / Kwiatkowski, D.; Cannon, J. G.; Manogue, K. R.; Cerami, A.; Dinarello, C. A.; Greenwood, B. M.

In: Clinical and Experimental Immunology, Vol. 77, No. 3, 01.01.1989, p. 361-366.

Research output: Contribution to journalArticle

Kwiatkowski, D, Cannon, JG, Manogue, KR, Cerami, A, Dinarello, CA & Greenwood, BM 1989, 'Tumour necrosis factor production in Falciparum malaria and its association with schizont rupture', Clinical and Experimental Immunology, vol. 77, no. 3, pp. 361-366.
Kwiatkowski D, Cannon JG, Manogue KR, Cerami A, Dinarello CA, Greenwood BM. Tumour necrosis factor production in Falciparum malaria and its association with schizont rupture. Clinical and Experimental Immunology. 1989 Jan 1;77(3):361-366.
Kwiatkowski, D. ; Cannon, J. G. ; Manogue, K. R. ; Cerami, A. ; Dinarello, C. A. ; Greenwood, B. M. / Tumour necrosis factor production in Falciparum malaria and its association with schizont rupture. In: Clinical and Experimental Immunology. 1989 ; Vol. 77, No. 3. pp. 361-366.
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