Summary: Genes responsible for the hereditary predisposition to a variety of human cancers have now been isolated. Their function seems to be part of complex signalling pathways involved in the control of cellular differentiation and the cell cycle. The presence of a single copy of these genes appears to be sufficient to ensure normal development, i.e. prevents tumorigenesis, and has earned them the name -tumour suppressor genes.
|Original language||English (US)|
|Number of pages||6|
|Journal||Annals of Oncology|
|Publication status||Published - Nov 1 1992|
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