Tunable Polymer Embolic Implant for Vascular Occlusion

Selva Jeganathan, Emily Budziszewski, Christopher Hernandez, Hanping Wu, Danielle Gilbert, Sidhartha Tavri, Agata A. Exner

Research output: Contribution to journalArticlepeer-review

Abstract

In this study, we have developed a tunable polymer vascular embolic implant (TPVEI) with adjustable precipitation rates allowing for personalized, controlled vascular occlusion depths. We hypothesized that reducing the water miscibility of the solvent would result in slower TPVEI precipitation, leading to distal vascular occlusion. To investigate homogeneous vascular distribution and occlusion control, the TPVEI was directly injected into the portal vein of a rat and imaged with microCT. Changing the solvent ratio of NMP/BB from 100/0 to 50/50 showed a significant (p < 0.05) decrease in vessel size occluded from 675 ± 20 to 170 ± 25 μm, respectively. The 60/40 (NMP/BB) formulation was able to occlude several branches throughout the whole liver, displaying a homogeneous vasculature distribution. Broadband Doppler ultrasound validated that there was complete portal vein occlusion after embolization with all materials. These findings suggest that adjusting the solvent polarity allows embolization control and with appropriate optimization, phase-inverting embolics could be used better to control depth of occlusion for endovascular therapies.

Original languageEnglish (US)
Pages (from-to)1849-1856
Number of pages8
JournalACS Biomaterials Science and Engineering
Volume5
Issue number4
DOIs
StatePublished - Apr 8 2019
Externally publishedYes

Keywords

  • embolization
  • in situ forming implant
  • PLGA
  • precipitation rate
  • vascular occlusion

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering

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