Two birds with one stone: A novel motif for ACh receptor assembly quality control

Lin Mei, Wencheng Xiong

Research output: Contribution to journalReview article

8 Citations (Scopus)

Abstract

Assembly of ACh receptors is under tight quality control. Only functional ACh receptors are expressed on the cell surface; unassembled subunits are retained in the endoplasmic reticulum (ER). In a recent elegant study, Wang and colleagues have identified a novel motif in the M1 domain of the ACh-receptor subunit that is responsible for ER retention and degradation of unassembled subunits. This signal appears to play an important role in regulating surface trafficking of functional ACh receptors.

Original languageEnglish (US)
Pages (from-to)178-181
Number of pages4
JournalTrends in Neurosciences
Volume26
Issue number4
DOIs
StatePublished - Apr 1 2003

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Cholinergic Receptors
Quality Control
Endoplasmic Reticulum

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Two birds with one stone : A novel motif for ACh receptor assembly quality control. / Mei, Lin; Xiong, Wencheng.

In: Trends in Neurosciences, Vol. 26, No. 4, 01.04.2003, p. 178-181.

Research output: Contribution to journalReview article

Mei, Lin ; Xiong, Wencheng. / Two birds with one stone : A novel motif for ACh receptor assembly quality control. In: Trends in Neurosciences. 2003 ; Vol. 26, No. 4. pp. 178-181.
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