Two birds with one stone: A novel motif for ACh receptor assembly quality control

Lin Mei, Wencheng Xiong

Research output: Contribution to journalReview article

8 Scopus citations


Assembly of ACh receptors is under tight quality control. Only functional ACh receptors are expressed on the cell surface; unassembled subunits are retained in the endoplasmic reticulum (ER). In a recent elegant study, Wang and colleagues have identified a novel motif in the M1 domain of the ACh-receptor subunit that is responsible for ER retention and degradation of unassembled subunits. This signal appears to play an important role in regulating surface trafficking of functional ACh receptors.

Original languageEnglish (US)
Pages (from-to)178-181
Number of pages4
JournalTrends in Neurosciences
Issue number4
StatePublished - Apr 1 2003


ASJC Scopus subject areas

  • Neuroscience(all)

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