Type II pneumocytes in pulmonary tumors. Implications for histogenesis

Gurmukh Singh, S. L. Katyal, N. G. Ordonez, D. H. Dail, Y. Negishi, V. W. Weedn, P. B. Marcus, C. M. Weldon-Linne, C. A. Axiotis, E. Alvarez-Fernandez

Research output: Contribution to journalArticle

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Abstract

Bronchioloalveolar carcinomas (n = 45), intravascular bronchiolo-alveolar tumors (n = 8), and sclerosing hemangiomas of the lung (n = 2) were stained for surfactant apoprotein by the immunoperoxidase method. Of the bronchiolo-alveolar carcinomas, 12 were found to be carcinomas of type II pneumocytes and the remaining 33 tumors were designated as nontype II pneumocytic bronchiolo-alveolar carcinomas. Twenty-five of these tumors displayed trapped benign type II pneumocytes with the tumor masses. In the case of intravascular bronchiolo-alveolar tumors, none of the tumors demonstrated staining of tumor cells for surfactant apoprotein. In the two cases of sclerosing hemangiomas, the type II pneumocytes were exuberant and numerous, and in one case contained intranuclear inclusions of surfactant apoprotein. This article discusses the implication of the presence of benign type II pneumocytes in pulmonary tumors.

Original languageEnglish (US)
Pages (from-to)44-48
Number of pages5
JournalArchives of Pathology and Laboratory Medicine
Volume108
Issue number1
StatePublished - Mar 1 1984
Externally publishedYes

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Alveolar Epithelial Cells
Lung
Bronchiolo-Alveolar Adenocarcinoma
Apoproteins
Neoplasms
Surface-Active Agents
Pulmonary Sclerosing Hemangioma
Benign Fibrous Histiocytoma
Intranuclear Inclusion Bodies
Staining and Labeling
Carcinoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology

Cite this

Singh, G., Katyal, S. L., Ordonez, N. G., Dail, D. H., Negishi, Y., Weedn, V. W., ... Alvarez-Fernandez, E. (1984). Type II pneumocytes in pulmonary tumors. Implications for histogenesis. Archives of Pathology and Laboratory Medicine, 108(1), 44-48.

Type II pneumocytes in pulmonary tumors. Implications for histogenesis. / Singh, Gurmukh; Katyal, S. L.; Ordonez, N. G.; Dail, D. H.; Negishi, Y.; Weedn, V. W.; Marcus, P. B.; Weldon-Linne, C. M.; Axiotis, C. A.; Alvarez-Fernandez, E.

In: Archives of Pathology and Laboratory Medicine, Vol. 108, No. 1, 01.03.1984, p. 44-48.

Research output: Contribution to journalArticle

Singh, G, Katyal, SL, Ordonez, NG, Dail, DH, Negishi, Y, Weedn, VW, Marcus, PB, Weldon-Linne, CM, Axiotis, CA & Alvarez-Fernandez, E 1984, 'Type II pneumocytes in pulmonary tumors. Implications for histogenesis', Archives of Pathology and Laboratory Medicine, vol. 108, no. 1, pp. 44-48.
Singh G, Katyal SL, Ordonez NG, Dail DH, Negishi Y, Weedn VW et al. Type II pneumocytes in pulmonary tumors. Implications for histogenesis. Archives of Pathology and Laboratory Medicine. 1984 Mar 1;108(1):44-48.
Singh, Gurmukh ; Katyal, S. L. ; Ordonez, N. G. ; Dail, D. H. ; Negishi, Y. ; Weedn, V. W. ; Marcus, P. B. ; Weldon-Linne, C. M. ; Axiotis, C. A. ; Alvarez-Fernandez, E. / Type II pneumocytes in pulmonary tumors. Implications for histogenesis. In: Archives of Pathology and Laboratory Medicine. 1984 ; Vol. 108, No. 1. pp. 44-48.
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