Ubc9 deficiency selectively impairs the functionality of common lymphoid progenitors (CLPs) during bone marrow hematopoiesis

Mohammed Abdelssalam Hassan Edrees, Jiahui Luo, Fei Sun, Faxi Wang, Long He, Tiantian Yue, Longmin Chen, Jing Zhang, Haifeng Zhou, Chunliang Yang, Ping Yang, Fei Xiong, Qilin Yu, Bao Ling Adam, Furong Liu, Jinxiu Li, Shu Zhang, Cong Yi Wang

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Hematopoietic development occurs in the bone marrow, and this process begins with hematopoietic stem cells (HSCs). Ubc9 is a unique E2-conjugating enzyme required for SUMOylation, an evolutionarily conserved post-translational modification system. We herein show that a conditional Ubc9 deletion in the hematopoietic system caused decreased thymus weight and reduced lymphocyte to myeloid cell ratio. Importantly, Ubc9 deletion in the hematopoietic system only selectively impaired the development of common lymphoid progenitors (CLPs) in the bone marrow and perturbed their potential to differentiate into lymphocytes, thereby decreasing the number of T/B cells in the periphery. Ubc9 was found to be required for CLP viability, and therefore, Ubc9 deficiency rendered CLPs to undergo apoptosis and attenuated their proliferation. Thus, Ubc9 plays a critical role in the regulation of CLP function during hematopoietic development in the bone marrow.

Original languageEnglish (US)
Pages (from-to)314-322
Number of pages9
JournalMolecular Immunology
Volume114
DOIs
StatePublished - Oct 2019

Keywords

  • Common lymphoid progenitors
  • Hematopoietic development
  • Ubc9

ASJC Scopus subject areas

  • Immunology
  • Molecular Biology

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