TY - JOUR
T1 - Ubc9 deficiency selectively impairs the functionality of common lymphoid progenitors (CLPs) during bone marrow hematopoiesis
AU - Edrees, Mohammed Abdelssalam Hassan
AU - Luo, Jiahui
AU - Sun, Fei
AU - Wang, Faxi
AU - He, Long
AU - Yue, Tiantian
AU - Chen, Longmin
AU - Zhang, Jing
AU - Zhou, Haifeng
AU - Yang, Chunliang
AU - Yang, Ping
AU - Xiong, Fei
AU - Yu, Qilin
AU - Adam, Bao Ling
AU - Liu, Furong
AU - Li, Jinxiu
AU - Zhang, Shu
AU - Wang, Cong Yi
N1 - Funding Information:
This study was supported by the National Natural Science Foundation of China (81530024, 9174920038, 81471046, 81770823 and 81670929), the Ministry of Science and Technology (2016YFC1305002 and 2017YFC1309603), NHC Drug Discovery Program (2017ZX09304022-07), the Department of Science and Technology of Hubei State (2017ACA096), the Integrated Innovative Team for Major Human Disease Programs of Tongji Medical College, Huazhong University of Science and Technology, and the Innovative Funding for Translational Research from Tongji Hospital.
Funding Information:
This study was supported by the National Natural Science Foundation of China ( 81530024 , 9174920038 , 81471046 , 81770823 and 81670929 ), the Ministry of Science and Technology ( 2016YFC1305002 and 2017YFC1309603 ), NHC Drug Discovery Program ( 2017ZX09304022-07 ), the Department of Science and Technology of Hubei State ( 2017ACA096 ), the Integrated Innovative Team for Major Human Disease Programs of Tongji Medical College, Huazhong University of Science and Technology, and the Innovative Funding for Translational Research from Tongji Hospital.
Publisher Copyright:
© 2019 Elsevier Ltd
PY - 2019/10
Y1 - 2019/10
N2 - Hematopoietic development occurs in the bone marrow, and this process begins with hematopoietic stem cells (HSCs). Ubc9 is a unique E2-conjugating enzyme required for SUMOylation, an evolutionarily conserved post-translational modification system. We herein show that a conditional Ubc9 deletion in the hematopoietic system caused decreased thymus weight and reduced lymphocyte to myeloid cell ratio. Importantly, Ubc9 deletion in the hematopoietic system only selectively impaired the development of common lymphoid progenitors (CLPs) in the bone marrow and perturbed their potential to differentiate into lymphocytes, thereby decreasing the number of T/B cells in the periphery. Ubc9 was found to be required for CLP viability, and therefore, Ubc9 deficiency rendered CLPs to undergo apoptosis and attenuated their proliferation. Thus, Ubc9 plays a critical role in the regulation of CLP function during hematopoietic development in the bone marrow.
AB - Hematopoietic development occurs in the bone marrow, and this process begins with hematopoietic stem cells (HSCs). Ubc9 is a unique E2-conjugating enzyme required for SUMOylation, an evolutionarily conserved post-translational modification system. We herein show that a conditional Ubc9 deletion in the hematopoietic system caused decreased thymus weight and reduced lymphocyte to myeloid cell ratio. Importantly, Ubc9 deletion in the hematopoietic system only selectively impaired the development of common lymphoid progenitors (CLPs) in the bone marrow and perturbed their potential to differentiate into lymphocytes, thereby decreasing the number of T/B cells in the periphery. Ubc9 was found to be required for CLP viability, and therefore, Ubc9 deficiency rendered CLPs to undergo apoptosis and attenuated their proliferation. Thus, Ubc9 plays a critical role in the regulation of CLP function during hematopoietic development in the bone marrow.
KW - Common lymphoid progenitors
KW - Hematopoietic development
KW - Ubc9
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U2 - 10.1016/j.molimm.2019.08.003
DO - 10.1016/j.molimm.2019.08.003
M3 - Article
C2 - 31442915
AN - SCOPUS:85070871779
VL - 114
SP - 314
EP - 322
JO - Molecular Immunology
JF - Molecular Immunology
SN - 0161-5890
ER -