Ultrasound diagnosis of multiple anomalies associated with prenatal oral contraceptives

J. A. Hill, P. A. Gantt, Paul G McDonough, J. J. Cunningham

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The case of a 22-year old woman with 1 child who became pregnant soon after initiating use of Ortho-Novum 1 + 50 pills is described. The patient had smoked 20-30 cigarettes/day for 2 years. There was no history of exposure to other potential teratogens or of maternal illnesses, and the family history was noncontributory. At 26 weeks gestation, real-time and B-scan ultrasound examination revealed the absence of a cranium and other anomalies. Labor was induced with prostaglandin E2 suppositories, and the patient spontaneously delivered a female fetus with severe anomalies, which autopsy revealed to include encephalocele containing residual brain tissue, cleft lip and palate, gastroschisis, thoracoschisis, and agenesis of the left upper extremity. A 2-vessel umbilical cord was noted. Maternal serum and amniotic fluid alpha fetoprotein were more than 2 standard deviations from the normal mean for the gestational age. The case appears to support the finding in previous studies of an association between smoking more than 20 cigarettes/day, oral contraceptive use during pregnancy, and congenital malformations. Ultrasound should be offered as a fetal malformation screening technique during the 2nd trimester of pregnancy to women with a history of prenatal hormone exposure.

Original languageEnglish (US)
Pages (from-to)116-118
Number of pages3
JournalMedical Ultrasound
Volume6
Issue number3
StatePublished - Dec 1 1982

Fingerprint

Oral Contraceptives
Tobacco Products
Single Umbilical Artery
Mothers
Induced Labor
Gastroschisis
Pregnancy Trimesters
Encephalocele
Teratogens
Pregnancy
Suppositories
Umbilical Cord
Cleft Lip
alpha-Fetoproteins
Cleft Palate
Amniotic Fluid
Dinoprostone
Skull
Upper Extremity
Gestational Age

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Hill, J. A., Gantt, P. A., McDonough, P. G., & Cunningham, J. J. (1982). Ultrasound diagnosis of multiple anomalies associated with prenatal oral contraceptives. Medical Ultrasound, 6(3), 116-118.

Ultrasound diagnosis of multiple anomalies associated with prenatal oral contraceptives. / Hill, J. A.; Gantt, P. A.; McDonough, Paul G; Cunningham, J. J.

In: Medical Ultrasound, Vol. 6, No. 3, 01.12.1982, p. 116-118.

Research output: Contribution to journalArticle

Hill, JA, Gantt, PA, McDonough, PG & Cunningham, JJ 1982, 'Ultrasound diagnosis of multiple anomalies associated with prenatal oral contraceptives', Medical Ultrasound, vol. 6, no. 3, pp. 116-118.
Hill JA, Gantt PA, McDonough PG, Cunningham JJ. Ultrasound diagnosis of multiple anomalies associated with prenatal oral contraceptives. Medical Ultrasound. 1982 Dec 1;6(3):116-118.
Hill, J. A. ; Gantt, P. A. ; McDonough, Paul G ; Cunningham, J. J. / Ultrasound diagnosis of multiple anomalies associated with prenatal oral contraceptives. In: Medical Ultrasound. 1982 ; Vol. 6, No. 3. pp. 116-118.
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