Abstract
We hypothesized that capillary recruitment may not be solely dependent on extracapillary factors. To test this hypothesis, rabbits were anesthetized and placed on total cardiac bypass at a constant, physiological pulmonary blood flow. Vascular occlusion techniques were combined with measurement of the transpulmonary metabolism of an angiotensin-converting enzyme substrate, allowing the concomitant assessment of changes in segmental resistances and dynamically perfused capillary surface area. Intra-arterial serotonin infusion increased upstream pulmonary vascular resistances without affecting dynamically perfused capillary surface area. Intra-arterial isoproterenol infusion diminished serotonin-induced increased upstream resistances, also without affecting capillary surface area. These findings support the hypothesis that pulmonary capillary recruitment may not be solely dependent on extracapillary factors.
Original language | English (US) |
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Pages (from-to) | L264-L269 |
Journal | American Journal of Physiology - Lung Cellular and Molecular Physiology |
Volume | 274 |
Issue number | 2 18-2 |
DOIs | |
State | Published - 1998 |
Keywords
- Capillary recruitment
- Isoproterenol
- Pulmonary circulation
- Pulmonary hypertension
- Rabbit
- Serotonin
ASJC Scopus subject areas
- Physiology
- Pulmonary and Respiratory Medicine
- Physiology (medical)
- Cell Biology