Understanding cadherin EGF LAG seven-pass G-type receptors

Xiao Jing Wang, Dao Lai Zhang, Zhi Gang Xu, Ming Liang Ma, Wen Bo Wang, Lin Lin Li, Xiao Lin Han, Yuqing Huo, Xiao Yu, Jin Peng Sun

Research output: Contribution to journalReview article

18 Scopus citations

Abstract

The cadherin epidermal growth factor (EGF) laminin G (LAG) seven-pass G-type receptors (CELSRs) are a special subgroup of adhesion G protein-coupled receptors, which are pivotal regulators of many biologic processes such as neuronal/endocrine cell differentiation, vessel valve formation, and the control of planar cell polarity during embryonic development. All three members of the CELSR family (CELSR1-3) have large ecto-domains that form homophilic interactions and encompass more than 2000 amino acids. Mutations in the ecto-domain or other gene locations of CELSRs are associated with neural tube defects and other diseases in humans. Celsr knockout (KO) animals have many developmental defects. Therefore, specific agonists or antagonists of CELSR members may have therapeutic potential. Although significant progress has been made regarding the functions and biochemical properties of CELSRs, our knowledge of these receptors is still lacking, especially considering that they are broadly distributed but have few characterized functions in a limited number of tissues. The dynamic activation and inactivation of CELSRs and the presence of endogenous ligands beyond homophilic interactions remain elusive, as do the regulatory mechanisms and downstream signaling of these receptors. Given this motivation, future studies with more advanced cell biology or biochemical tools, such as conditional KO mice, may provide further insights into the mechanisms underlying CELSR function, laying the foundation for the design of new CELSR-targeted therapeutic reagents.

Original languageEnglish (US)
Pages (from-to)699-711
Number of pages13
JournalJournal of Neurochemistry
Volume131
Issue number6
DOIs
StatePublished - Dec 1 2014

Keywords

  • CELSR
  • G protein-coupled receptor
  • adhesion
  • development
  • planar cell polarity

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

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  • Cite this

    Wang, X. J., Zhang, D. L., Xu, Z. G., Ma, M. L., Wang, W. B., Li, L. L., Han, X. L., Huo, Y., Yu, X., & Sun, J. P. (2014). Understanding cadherin EGF LAG seven-pass G-type receptors. Journal of Neurochemistry, 131(6), 699-711. https://doi.org/10.1111/jnc.12955