Understanding cadherin EGF LAG seven-pass G-type receptors

Xiao Jing Wang, Dao Lai Zhang, Zhi Gang Xu, Ming Liang Ma, Wen Bo Wang, Lin Lin Li, Xiao Lin Han, Yuqing Huo, Xiao Yu, Jin Peng Sun

Research output: Contribution to journalReview article

13 Citations (Scopus)

Abstract

The cadherin epidermal growth factor (EGF) laminin G (LAG) seven-pass G-type receptors (CELSRs) are a special subgroup of adhesion G protein-coupled receptors, which are pivotal regulators of many biologic processes such as neuronal/endocrine cell differentiation, vessel valve formation, and the control of planar cell polarity during embryonic development. All three members of the CELSR family (CELSR1-3) have large ecto-domains that form homophilic interactions and encompass more than 2000 amino acids. Mutations in the ecto-domain or other gene locations of CELSRs are associated with neural tube defects and other diseases in humans. Celsr knockout (KO) animals have many developmental defects. Therefore, specific agonists or antagonists of CELSR members may have therapeutic potential. Although significant progress has been made regarding the functions and biochemical properties of CELSRs, our knowledge of these receptors is still lacking, especially considering that they are broadly distributed but have few characterized functions in a limited number of tissues. The dynamic activation and inactivation of CELSRs and the presence of endogenous ligands beyond homophilic interactions remain elusive, as do the regulatory mechanisms and downstream signaling of these receptors. Given this motivation, future studies with more advanced cell biology or biochemical tools, such as conditional KO mice, may provide further insights into the mechanisms underlying CELSR function, laying the foundation for the design of new CELSR-targeted therapeutic reagents.

Original languageEnglish (US)
Pages (from-to)699-711
Number of pages13
JournalJournal of Neurochemistry
Volume131
Issue number6
DOIs
StatePublished - Jan 1 2015

Fingerprint

Laminin
Cadherins
Epidermal Growth Factor
Cell Polarity
Endocrine Cells
Neural Tube Defects
G-Protein-Coupled Receptors
Knockout Mice
Cytology
Embryonic Development
Cell Biology
Motivation
Cell Differentiation
Defects
Ligands
Amino Acids
Mutation
Animals
Therapeutics
Adhesion

Keywords

  • CELSR
  • G protein-coupled receptor
  • adhesion
  • development
  • planar cell polarity

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

Cite this

Wang, X. J., Zhang, D. L., Xu, Z. G., Ma, M. L., Wang, W. B., Li, L. L., ... Sun, J. P. (2015). Understanding cadherin EGF LAG seven-pass G-type receptors. Journal of Neurochemistry, 131(6), 699-711. https://doi.org/10.1111/jnc.12955

Understanding cadherin EGF LAG seven-pass G-type receptors. / Wang, Xiao Jing; Zhang, Dao Lai; Xu, Zhi Gang; Ma, Ming Liang; Wang, Wen Bo; Li, Lin Lin; Han, Xiao Lin; Huo, Yuqing; Yu, Xiao; Sun, Jin Peng.

In: Journal of Neurochemistry, Vol. 131, No. 6, 01.01.2015, p. 699-711.

Research output: Contribution to journalReview article

Wang, XJ, Zhang, DL, Xu, ZG, Ma, ML, Wang, WB, Li, LL, Han, XL, Huo, Y, Yu, X & Sun, JP 2015, 'Understanding cadherin EGF LAG seven-pass G-type receptors', Journal of Neurochemistry, vol. 131, no. 6, pp. 699-711. https://doi.org/10.1111/jnc.12955
Wang XJ, Zhang DL, Xu ZG, Ma ML, Wang WB, Li LL et al. Understanding cadherin EGF LAG seven-pass G-type receptors. Journal of Neurochemistry. 2015 Jan 1;131(6):699-711. https://doi.org/10.1111/jnc.12955
Wang, Xiao Jing ; Zhang, Dao Lai ; Xu, Zhi Gang ; Ma, Ming Liang ; Wang, Wen Bo ; Li, Lin Lin ; Han, Xiao Lin ; Huo, Yuqing ; Yu, Xiao ; Sun, Jin Peng. / Understanding cadherin EGF LAG seven-pass G-type receptors. In: Journal of Neurochemistry. 2015 ; Vol. 131, No. 6. pp. 699-711.
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